Cell Biology Antibodies 14

Anti-PURB Antibody (CAB18166)

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SKU:
CAB18166
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PURB Antibody
Antibody SKU:CAB18166
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human PURB.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:LO2, HeLa
Immunogen:Recombinant protein of human PURB.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5814
Uniprot:Q96QR8
Cellular Location:
Calculated MW:33kDa
Observed MW:38kDa
Anti-PURB Antibody (CAB18166)Western blot - PURB Polyclonal Antibody (CAB18166)
Synonyms:PURB, PURBETA
Background:This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
UniProt Protein Function:Pur-beta: Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs. Belongs to the PUR DNA-binding protein family.
UniProt Protein Details:

Protein type:RNA-binding; DNA-binding

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: DNA replication factor A complex; nucleus

Molecular Function:mRNA binding; single-stranded DNA binding; transcription factor binding

NCBI Summary:This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
UniProt Code:Q96QR8
NCBI GenInfo Identifier:74732688
NCBI Gene ID:5814
NCBI Accession:Q96QR8.3
UniProt Secondary Accession:Q96QR8,A4D2L7,
UniProt Related Accession:Q96QR8
Molecular Weight:33,241 Da
NCBI Full Name:Transcriptional activator protein Pur-beta
NCBI Synonym Full Names:purine rich element binding protein B
NCBI Official Symbol:PURB  
NCBI Official Synonym Symbols:PURBETA  
NCBI Protein Information:transcriptional activator protein Pur-beta
UniProt Protein Name:Transcriptional activator protein Pur-beta
UniProt Synonym Protein Names:Purine-rich element-binding protein B
Protein Family:Transcriptional activator protein
UniProt Gene Name:PURB  
UniProt Entry Name:PURB_HUMAN
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