Anti-Pumilio 2 Antibody (CAB19783)

(No reviews yet) Write a Review
SKU:
CAB19783
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PUMH2
Synonyms:
PUML2

Description

Product Name:Pumilio 2 Rabbit mAb
Product Code:CAB19783
Size:20uL, 50uL, 100uL
Synonyms:PUMH2, PUML2
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Pumilio 2
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:PC-3, Mouse testis, Rat testis
Immunogen:A synthesized peptide derived from human Pumilio 2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:23369
Uniprot:Q8TB72
Calculated MW:114kDa
Observed MW:110-125KDa
UniProt Protein Function:Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells.
UniProt Protein Details:
NCBI Summary:This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
UniProt Code:Q8TB72
NCBI GenInfo Identifier:41688714
NCBI Gene ID:23369
NCBI Accession:Q8TB72.2
UniProt Secondary Accession:Q8TB72,O00234, Q53TV7, Q8WY43, Q9HAN2, B3KSL0, B4E2B6 D6W527
UniProt Related Accession:Q8TB72
Molecular Weight:107,646 Da
NCBI Full Name:Pumilio homolog 2
NCBI Synonym Full Names:pumilio RNA binding family member 2
NCBI Official Symbol:PUM2  
NCBI Official Synonym Symbols:PUMH2; PUML2  
NCBI Protein Information:pumilio homolog 2
UniProt Protein Name:Pumilio homolog 2
UniProt Synonym Protein Names:
Protein Family:Pumilio
UniProt Gene Name:PUM2  
UniProt Entry Name:PUM2_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products