Cell Biology Antibodies 17

Anti-PUMA Antibody (CAB3752)

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SKU:
CAB3752
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PUMA Antibody
Antibody SKU:CAB3752
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human PUMA
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, A-549, NIH/3T3, K-562, LO2, Mouse lung, Mouse spleen, Rat liver
Immunogen:A synthesized peptide derived from human PUMA
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:27113
Uniprot:Q96PG8/Q9BXH1
Cellular Location:
Calculated MW:18kDa
Observed MW:18KDa/23KDa
Synonyms:JFY-1, JFY1, PUMA
Background:This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
UniProt Protein Function:BBC3B: Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Isoform 3 fails to show any growth- inhibitory or apoptotic activity. Induced by DNA damage, glucocorticoid treatment, growth factor deprivation and p53/TP53. {ECO:0000269|PubMed:11463392}. Isoform 3 does not interact with BCL2. 4 isoforms of the human protein are produced by alternative splicing
UniProt Protein Details:

Protein type:Apoptosis; Mitochondrial

Chromosomal Location of Human Ortholog: 19q13.3-q13.4

Cellular Component: lysosome; mitochondrion

Molecular Function:ATPase binding; glycoprotein binding; protein binding

Biological Process: apoptosis

NCBI Summary:This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
UniProt Code:Q96PG8
NCBI GenInfo Identifier:391738062
NCBI Gene ID:27113
NCBI Accession:Q96PG8.2
UniProt Related Accession:Q9BXH1,Q96PG8
Molecular Weight:20,532 Da
NCBI Full Name:Bcl-2-binding component 3
NCBI Synonym Full Names:BCL2 binding component 3
NCBI Official Symbol:BBC3  
NCBI Official Synonym Symbols:JFY1; PUMA; JFY-1  
NCBI Protein Information:bcl-2-binding component 3
UniProt Protein Name:Bcl-2-binding component 3
UniProt Synonym Protein Names:JFY-1; p53 up-regulated modulator of apoptosis
Protein Family:Bcl-2-binding component
UniProt Gene Name:BBC3  
UniProt Entry Name:BBC3B_HUMAN
Anti-PUMA Antibody (CAB3752)Western blot - PUMA Rabbit mAb (CAB3752)
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