Signal Transduction Antibodies 1
Anti-PTX3 Antibody (CAB12669)
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- SKU:
- CAB12669
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-PTX3 Antibody |
| Antibody SKU: | CAB12669 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-240 of human PTX3 (NP_002843.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A375, HL-60, HepG2, Jurkat, NIH/3T3, Mouse liver, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-240 of human PTX3 (NP_002843.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ENSD DYDL MYVN LDNE IDNG LHPT EDPT PCAC GQEH SEWD KLFI MLEN SQMR ERML LQAT DDVL RGEL QRLR EELG RLAE SLAR PCAP GAPA EARL TSAL DELL QATR DAGR RLAR MEGA EAQR PEEA GRAL AAVL EELR QTRA DLHA VQGW AARS WLPA GCET AILF PMRS KKIF GSVH PVRP MRLE SFSA CIWV KATD VLNK TILF SYGT KRNP YEIQ LYL |
| Gene ID: | 5806 |
| Uniprot: | P26022 |
| Cellular Location: | Secreted |
| Calculated MW: | 41kDa |
| Observed MW: | 42kDa |
| Synonyms: | PTX3, TNFAIP5, TSG-14 |
| Background: | This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. |
| UniProt Protein Function: | PTX3: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 3q25 Cellular Component: extracellular space; extracellular region Molecular Function:complement component C1q binding; zymosan binding; virion binding Biological Process: positive regulation of nitric oxide biosynthetic process; negative regulation of virion penetration into host cell; positive regulation of phagocytosis; innate immune response; response to yeast; opsonization; inflammatory response |
| UniProt Code: | P26022 |
| NCBI GenInfo Identifier: | 296452984 |
| NCBI Gene ID: | 5806 |
| NCBI Accession: | P26022.3 |
| UniProt Secondary Accession: | P26022,Q38M82, B2R6T6, |
| UniProt Related Accession: | P26022 |
| Molecular Weight: | 41,976 Da |
| NCBI Full Name: | Pentraxin-related protein PTX3 |
| NCBI Synonym Full Names: | pentraxin 3, long |
| NCBI Official Symbol: | PTX3 |
| NCBI Official Synonym Symbols: | TSG-14; TNFAIP5 |
| NCBI Protein Information: | pentraxin-related protein PTX3; pentraxin-3; TNF alpha-induced protein 5; pentaxin-related protein PTX3; tumor necrosis factor alpha-induced protein 5; tumor necrosis factor, alpha-induced protein 5; tumor necrosis factor-inducible protein TSG-14; tumor necrosis factor-inducible gene 14 protein; pentraxin-related gene, rapidly induced by IL-1 beta; pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor, alpha-induced protein 5 |
| UniProt Protein Name: | Pentraxin-related protein PTX3 |
| UniProt Synonym Protein Names: | Pentaxin-related protein PTX3; Tumor necrosis factor alpha-induced protein 5; TNF alpha-induced protein 5; Tumor necrosis factor-inducible gene 14 protein; TSG-14 |
| Protein Family: | Pentraxin-related protein |
| UniProt Gene Name: | PTX3 |
| UniProt Entry Name: | PTX3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PTX3 antibody (CAB12669) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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