Name: Anti-PTS Antibody (CAB6306)
Brand: Metabolism Antibodies 2
SKU: CAB6306
Availability: OutOfStock

Antibody Name:	Anti-PTS Antibody
Antibody SKU:	CAB6306
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human PTS (NP_000308.1).

Application:	WB IF
Recommended Dilution:	WB 1:500 - 1:2000 IF 1:10 - 1:100
Reactivity:	Human, Mouse, Rat
Positive Samples:	HeLa, U-251MG, Mouse liver, Mouse kidney

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human PTS (NP_000308.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MSTE GGGR RCQA QVSR RISF SASH RLYS KFLS DEEN LKLF GKCN NPNG HGHN YKVV VTVH GEID PATG MVMN LADL KKYM EEAI MQPL DHKN LDMD VPYF ADVV STTE NVAV YIWD NLQK VLPV GVLY KVKV YETD NNIV VYKG E
Gene ID:	5805
Uniprot:	Q03393
Cellular Location:
Calculated MW:	16kDa
Observed MW:	16kDa

Synonyms:

PTS, PTPS

Background:

The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia.

UniProt Protein Function:	PTS: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin. Defects in PTS are the cause of BH4-deficient hyperphenylalaninemia type A (HPABH4A); also called 6-pyruvoyl-tetrahydropterin synthase deficiency (PTS deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to PTS deficiency. HPABH4A is an autosomal recessive disorder characterized by depletion of the neurotransmitters dopamine and serotonin, and clinically by severe neurological symptoms unresponsive to the classic phenylalanine-low diet. Belongs to the PTPS family.
UniProt Protein Details:	Protein type:Mitochondrial; Cofactor and Vitamin Metabolism - folate biosynthesis; Lyase; EC 4.2.3.12 Chromosomal Location of Human Ortholog: 11q22.3 Cellular Component: mitochondrion; cytoplasm; cytosol Molecular Function:identical protein binding; protein homodimerization activity; metal ion binding; 6-pyruvoyltetrahydropterin synthase activity Biological Process: amino acid metabolic process; tetrahydrobiopterin biosynthetic process; central nervous system development; regulation of nitric-oxide synthase activity; nitric oxide metabolic process Disease: Hyperphenylalaninemia, Bh4-deficient, A
NCBI Summary:	The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq, Oct 2008]
UniProt Code:	Q03393
NCBI GenInfo Identifier:	417553
NCBI Gene ID:	5805
NCBI Accession:	Q03393.1
UniProt Secondary Accession:	Q03393,Q8WVG8, B0YJ87,
UniProt Related Accession:	Q03393
Molecular Weight:	145
NCBI Full Name:	6-pyruvoyl tetrahydrobiopterin synthase
NCBI Synonym Full Names:	6-pyruvoyltetrahydropterin synthase
NCBI Official Symbol:	PTS
NCBI Official Synonym Symbols:	PTPS
NCBI Protein Information:	6-pyruvoyl tetrahydrobiopterin synthase; PTP synthase
UniProt Protein Name:	6-pyruvoyl tetrahydrobiopterin synthase
Protein Family:	PTS system EIIBC component
UniProt Gene Name:	PTS
UniProt Entry Name:	PTPS_HUMAN

Western blot analysis of extracts of various cell lines, using PTS antibody (CAB6306) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

Antibodies

Anti-PTS Antibody (CAB14055)

PTS Antibody (PACO11605)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)