Cell Biology Antibodies 12
Anti-PTPRS Antibody (CAB8866)
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- SKU:
- CAB8866
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PTPRS Antibody |
| Antibody SKU: | CAB8866 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1100-1280 of human PTPRS (NP_002841.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1100-1280 of human PTPRS (NP_002841.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TNRG SSLG GLQQ TVTA WTAF NLLN GKPS VAPK PDAD GFIM VYLP DGQS PVPV QSYF IVMV PLRK SRGG QFLT PLGS PEDM DLEE LIQD ISRL QRRS LRHS RQLE VPRP YIAA RFSV LPPT FHPG DQKQ YGGF DNRG LEPG HRYV LFVL AVLQ KSEP TFAA SPFS DPFQ LDNP DPQP IVDG E |
| Gene ID: | 5802 |
| Uniprot: | Q13332 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 168kDa/171kDa/212kDa/214kDa/215kDa/217kDa |
| Observed MW: | 220kDa |
| Synonyms: | PTPRS, PTPSIGMA, R-PTP-S, R-PTP-sigma |
| Background: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. |
| UniProt Protein Function: | PTPRS: Interacts with LAR-interacting protein LIP.1. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 3.1.3.48; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: integral to plasma membrane Molecular Function:protein binding; transmembrane receptor protein tyrosine phosphatase activity Biological Process: corpus callosum development; extracellular matrix organization and biogenesis; spinal cord development; hippocampus development; cerebellum development; cerebral cortex development; cell adhesion |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13332 |
| NCBI GenInfo Identifier: | 119589584 |
| NCBI Gene ID: | 5802 |
| NCBI Accession: | EAW69178.1 |
| UniProt Secondary Accession: | Q13332,O75255, O75870, Q15718, Q16341, Q2M3R7, |
| UniProt Related Accession: | Q13332 |
| Molecular Weight: | |
| NCBI Full Name: | protein tyrosine phosphatase, receptor type, S, isoform CRA_h |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, receptor type, S |
| NCBI Official Symbol: | PTPRS |
| NCBI Official Synonym Symbols: | PTPSIGMA |
| NCBI Protein Information: | receptor-type tyrosine-protein phosphatase S; R-PTP-S; R-PTP-sigma; protein tyrosine phosphatase PTPsigma; receptor-type tyrosine-protein phosphatase sigma; protein tyrosine phosphatase, receptor type, sigma |
| UniProt Protein Name: | Receptor-type tyrosine-protein phosphatase S |
| UniProt Synonym Protein Names: | Receptor-type tyrosine-protein phosphatase sigma |
| Protein Family: | Receptor-type tyrosine-protein phosphatase |
| UniProt Gene Name: | PTPRS |
| UniProt Entry Name: | PTPRS_HUMAN |
 | Western blot analysis of extracts of rat testis, using PTPRS antibody (CAB8866) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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