Cell Biology Antibodies 2

Anti-PTPRR Antibody (CAB12246)

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SKU:
CAB12246
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PTPRR Antibody
Antibody SKU:CAB12246
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 240-400 of human PTPRR (NP_002840.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, HT-29, Rat heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 240-400 of human PTPRR (NP_002840.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IIVT CLMI LYRL KERF QLSL RQDK EKNQ EIHL SPIT LQPA LSEA KTVH SMVQ PEQA PKVL NVVV DPQG RGAP EIKA TTAT SVCP SPFK MKPI GLQE RRGS NVSL TLDM SSLG NIEP FVSI PTPR EKVA MEYL QSAS RILT RSQL RDVV ASSH LLQS EFME I
Gene ID:5801
Uniprot:Q15256
Cellular Location:Cell membrane, Cytoplasm, Single-pass type I membrane protein, perinuclear region, perinuclear region
Calculated MW:46kDa/51kDa/61kDa/73kDa
Observed MW:50kDa
Synonyms:PTPRR, EC-PTP, PCPTP1, PTP-SL, PTPBR7, PTPRQ
Background:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12.
UniProt Protein Function:PTP-SL: Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; EC 3.1.3.48; Membrane protein, integral; Receptor protein phosphatase, tyrosine

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: extracellular space; perinuclear region of cytoplasm; integral to membrane; plasma membrane

Molecular Function:protein binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; protein kinase binding

Biological Process: in utero embryonic development; protein amino acid dephosphorylation

NCBI Summary:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]
UniProt Code:Q15256
NCBI GenInfo Identifier:134039192
NCBI Gene ID:5801
NCBI Accession:Q15256.2
UniProt Secondary Accession:Q15256,O00342, Q92682, Q9UE65, B2R5Z7, B7Z3J1, F5GXR7
UniProt Related Accession:Q15256
Molecular Weight:657
NCBI Full Name:Receptor-type tyrosine-protein phosphatase R
NCBI Synonym Full Names:protein tyrosine phosphatase, receptor type, R
NCBI Official Symbol:PTPRR  
NCBI Official Synonym Symbols:PTPRQ; EC-PTP; PCPTP1; PTP-SL; PTPBR7  
NCBI Protein Information:receptor-type tyrosine-protein phosphatase R; R-PTP-R; NC-PTPCOM1; ch-1PTPase; Ch-1 PTPase; protein-tyrosine phosphatase PCPTP1; protein tyrosine phosphatase Cr1PTPase; protein-tyrosine phosphatase NC-PTPCOM1
UniProt Protein Name:Receptor-type tyrosine-protein phosphatase R
UniProt Synonym Protein Names:Ch-1PTPase; NC-PTPCOM1; Protein-tyrosine phosphatase PCPTP1
Protein Family:Receptor-type tyrosine-protein phosphatase
UniProt Gene Name:PTPRR  
UniProt Entry Name:PTPRR_HUMAN
Anti-PTPRR Antibody (CAB12246)Western blot analysis of extracts of various cell lines, using PTPRR antibody (CAB12246) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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