Cell Biology Antibodies 1

Anti-PTPRJ Antibody (CAB10169)

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SKU:
CAB10169
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PTPRJ Antibody
Antibody SKU:CAB10169
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 140-370 of human PTPRJ (NP_002834.3).
Application:WB
Recommended Dilution:WB 1:200 - 1:1000
Reactivity:Human, Mouse
Positive Samples:Raji
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 140-370 of human PTPRJ (NP_002834.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KSND TAAS EYKY VVKH KMEN EKTI TVVH QPWC NITG LRPA TSYV FSIT PGIG NETW GDPR VIKV ITEP IPVS DLRV ALTG VRKA ALSW SNGN GTAS CRVL LESI GSHE ELTQ DSRL QVNI SGLK PGVQ YNIN PYLL QSNK TKGD PLGT EGGL DASN TERS RAGS PTAP VHDE SLVG PVDP SSGQ QSRD TEVL LVGL EPGT RYNA TVYS QAAN GTEG QPQA IEFR TNAI QVF
Gene ID:5795
Uniprot:Q12913
Cellular Location:Cell junction, Cell membrane, Cell projection, Single-pass type I membrane protein, ruffle membrane
Calculated MW:57kDa/145kDa
Observed MW:260kDa
Synonyms:PTPRJ, CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1
Background:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.
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NCBI Summary:
UniProt Code:Q12913
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UniProt Secondary Accession:Q12913
UniProt Related Accession:Q12913
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Anti-PTPRJ Antibody (CAB10169)Western blot analysis of extracts of Raji cells, using PTPRJ antibody (CAB10169) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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