Antibody Name:	Anti-PTPRE Antibody
Antibody SKU:	CAB7209
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human PTPRE (NP_006495.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	HL-60, SW620, Mouse brain, Mouse spleen, Mouse lung, Rat brain, Rat lung

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human PTPRE (NP_006495.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	LRGN ETTA DSNE TTTT SGPP DPGA SQPL LAWL LLPL LLLL LVLL LAAY FFRF RKQR KAVV STSD KKMP NGIL EEQE QQRV MLLS RSPS GPKK YFPI PVEH LEEE IRIR SADD CKQF REEF NSLP SGHI QGTF ELAN KEEN REKN RYPN ILPN DHSR VILS QLDG IPCS DYIN ASYI DGYK E
Gene ID:	5791
Uniprot:	P23469
Cellular Location:	Cell membrane, Cytoplasm, Cytoplasm, Single-pass type I membrane protein
Calculated MW:	71kDa/74kDa/80kDa
Observed MW:	81kDa

Synonyms:

PTPRE, HPTPE, PTPE, R-PTP-EPSILON

Background:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels.

UniProt Protein Function:	PTPRE: a cytoplasmic and transmembrane receptor protein tyrosine phosphatase that regulates IL-10 and TNFA biosynthesis, myelination and cell-matrix adhesion, overexpression reduces tumor development
UniProt Protein Details:	Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.1.3.48; Receptor protein phosphatase, tyrosine Chromosomal Location of Human Ortholog: 10q26 Cellular Component: cytoplasm; nucleus; plasma membrane Molecular Function:protein binding; transmembrane receptor protein tyrosine phosphatase activity Biological Process: negative regulation of insulin receptor signaling pathway; protein amino acid dephosphorylation
NCBI Summary:	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015]
UniProt Code:	P23469
NCBI GenInfo Identifier:	126471
NCBI Gene ID:	5791
NCBI Accession:	P23469.1
UniProt Secondary Accession:	P23469,Q13345, Q5VWH3, Q5VWH4, Q96KQ6,
UniProt Related Accession:	P23469
Molecular Weight:	71,382 Da
NCBI Full Name:	Receptor-type tyrosine-protein phosphatase epsilon
NCBI Synonym Full Names:	protein tyrosine phosphatase, receptor type E
NCBI Official Symbol:	PTPRE
NCBI Official Synonym Symbols:	PTPE; HPTPE; R-PTP-EPSILON
NCBI Protein Information:	receptor-type tyrosine-protein phosphatase epsilon
UniProt Protein Name:	Receptor-type tyrosine-protein phosphatase epsilon
Protein Family:	Receptor-type tyrosine-protein phosphatase
UniProt Gene Name:	PTPRE
UniProt Entry Name:	PTPRE_HUMAN

	Western blot analysis of extracts of various cell lines, using PTPRE antibody (CAB7209) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded rat brain using PTPRE antibody (CAB7209) at dilution of 1:100 (40x lens).