Cell Biology Antibodies 12

Anti-PTPRD Antibody (CAB8559)

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SKU:
CAB8559
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PTPRD Antibody
Antibody SKU:CAB8559
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 475-574 of human PTPRD (NP_002830.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:Human, Mouse
Positive Samples:HT-1080, DU145, B cells, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 475-574 of human PTPRD (NP_002830.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QITT IGNL VPQK TYSV KVLA FTSI GDGP LSSD IQVI TQTG VPGQ PLNF KAEP ESET SILL SWTP PRSD TIAN YELV YKDG EHGE EQRI TIEP GTSY RLQG
Gene ID:5789
Uniprot:P23468
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:156kDa/169kDa/212kDa/214kDa
Observed MW:180-215kDa
Synonyms:PTPRD, HPTP, HPTPD, HPTPDELTA, PTPD, RPTPDELTA
Background:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5.
NCBI Summary:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]
UniProt Code:P23468
NCBI GenInfo Identifier:1709906
NCBI Gene ID:5789
NCBI Accession:P23468.2
UniProt Secondary Accession:P23468,Q3KPJ0, Q3KPJ1, Q3KPJ2, B1ALA0, F5GWT7,
UniProt Related Accession:P23468
Molecular Weight:169,277 Da
NCBI Full Name:Receptor-type tyrosine-protein phosphatase delta
NCBI Synonym Full Names:protein tyrosine phosphatase, receptor type D
NCBI Official Symbol:PTPRD  
NCBI Official Synonym Symbols:HPTP; PTPD; HPTPD; HPTPDELTA; RPTPDELTA  
NCBI Protein Information:receptor-type tyrosine-protein phosphatase delta
UniProt Protein Name:Receptor-type tyrosine-protein phosphatase delta
Protein Family:Receptor-type tyrosine-protein phosphatase
UniProt Gene Name:PTPRD  
UniProt Entry Name:PTPRD_HUMAN
Anti-PTPRD Polyclonal Antibody (CAB8559)Western blot analysis of extracts of various cell lines, using PTPRD Antibody (CAB8559) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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