| Background: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010] |
| UniProt Code: | P23468 |
| NCBI GenInfo Identifier: | 1709906 |
| NCBI Gene ID: | 5789 |
| NCBI Accession: | P23468.2 |
| UniProt Secondary Accession: | P23468,Q3KPJ0, Q3KPJ1, Q3KPJ2, B1ALA0, F5GWT7, |
| UniProt Related Accession: | P23468 |
| Molecular Weight: | 169,277 Da |
| NCBI Full Name: | Receptor-type tyrosine-protein phosphatase delta |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, receptor type D |
| NCBI Official Symbol: | PTPRD |
| NCBI Official Synonym Symbols: | HPTP; PTPD; HPTPD; HPTPDELTA; RPTPDELTA |
| NCBI Protein Information: | receptor-type tyrosine-protein phosphatase delta |
| UniProt Protein Name: | Receptor-type tyrosine-protein phosphatase delta |
| Protein Family: | Receptor-type tyrosine-protein phosphatase |
| UniProt Gene Name: | PTPRD |
| UniProt Entry Name: | PTPRD_HUMAN |
