Cell Biology Antibodies 15

Anti-PTPRB Antibody (CAB6957)

(No reviews yet) Write a Review
SKU:
CAB6957
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-PTPRB Antibody
Antibody SKU:CAB6957
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1976-2215 of human PTPRB (NP_001103224.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1976-2215 of human PTPRB (NP_001103224.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:INAS YIPG NNFR REYI VTQG PLPG TKDD FWKM VWEQ NVHN IVMV TQCV EKGR VKCD HYWP ADQD SLYY GDLI LQML SESV LPEW TIRE FKIC GEEQ LDAH RLIR HFHY TVWP DHGV PETT QSLI QFVR TVRD YINR SPGA GPTV VHCS AGVG RTGT FIAL DRIL QQLD SKDS VDIY GAVH DLRL HRVH MVQT ECQY VYLH QCVR DVLR ARKL RSEQ ENPL FPIY ENVN PEYH RDPV YSRH
Gene ID:5787
Uniprot:P23467
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:214kDa/224kDa/249kDa
Observed MW:Refer to figures
Synonyms:PTPRB, HPTP-BETA, HPTPB, PTPB, R-PTP-BETA, VEPTP
Background:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:PTPRB: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: integral to plasma membrane; receptor complex

Molecular Function:protein binding; transmembrane receptor protein tyrosine phosphatase activity

Biological Process: dephosphorylation; phosphate metabolic process; protein amino acid dephosphorylation

NCBI Summary:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
UniProt Code:P23467
NCBI GenInfo Identifier:157952215
NCBI Gene ID:5787
NCBI Accession:NP_001103224.1
UniProt Secondary Accession:P23467,Q14D85, Q3MIV7, B7ZKS8, B7ZKT0, C9JX87, F5H3G6
UniProt Related Accession:P23467
Molecular Weight:224kDa
NCBI Full Name:receptor-type tyrosine-protein phosphatase beta isoform a
NCBI Synonym Full Names:protein tyrosine phosphatase, receptor type B
NCBI Official Symbol:PTPRB  
NCBI Official Synonym Symbols:PTPB; HPTPB; VEPTP; HPTP-BETA; R-PTP-BETA  
NCBI Protein Information:receptor-type tyrosine-protein phosphatase beta
UniProt Protein Name:Receptor-type tyrosine-protein phosphatase beta
UniProt Synonym Protein Names:Vascular endothelial protein tyrosine phosphatase; VE-PTP
Protein Family:Receptor-type tyrosine-protein phosphatase
UniProt Gene Name:PTPRB  
View AllClose

0 Reviews

View AllClose

Related Products