Cell Biology Antibodies 9
Anti-PTPN7 Antibody (CAB4062)
- SKU:
- CAB4062
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-PTPN7 Antibody |
Antibody SKU: | CAB4062 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human PTPN7 (NP_542155.1). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human |
Positive Samples: | Raji, MCF7 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human PTPN7 (NP_542155.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MGAS FWPI RQAR EQQR RALS FRQT SWLS EPPL GPAP HLSM VQAH GGRS RAQP LTLS LGAA MTQP PPEK TPAK KHVR LQER RGSN VALM LDVR SLGA VEPI CSVN TPRE VTLH FLRT AGHP LTRW ALQR QPPS PKQL EEEF LKIP SNFV SPED LDIP GHAS KDRY KTIL PNPQ SRVC LGRA QSQE DGDY IN |
Gene ID: | 5778 |
Uniprot: | P35236 |
Cellular Location: | Cytoplasm, cytoskeleton |
Calculated MW: | 40kDa/45kDa/52kDa |
Observed MW: | 40kDa |
Synonyms: | PTPN7, BPTP-4, HEPTP, LC-PTP, LPTP, PTPNI |
Background: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. |
UniProt Protein Function: | Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. |
NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010] |
UniProt Code: | P35236 |
NCBI GenInfo Identifier: | 20141721 |
NCBI Gene ID: | 5778 |
NCBI Accession: | P35236.3 |
UniProt Secondary Accession: | P35236,Q53XK4, Q5SXQ0, Q5SXQ1, Q9BV05, B3KXE1, |
UniProt Related Accession: | P35236 |
Molecular Weight: | 52,284 Da |
NCBI Full Name: | Tyrosine-protein phosphatase non-receptor type 7 |
NCBI Synonym Full Names: | protein tyrosine phosphatase, non-receptor type 7 |
NCBI Official Symbol: | PTPN7 |
NCBI Official Synonym Symbols: | LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP |
NCBI Protein Information: | tyrosine-protein phosphatase non-receptor type 7 |
UniProt Protein Name: | Tyrosine-protein phosphatase non-receptor type 7 |
UniProt Synonym Protein Names: | Hematopoietic protein-tyrosine phosphatase; HEPTP; Protein-tyrosine phosphatase LC-PTP |
Protein Family: | Tyrosine-protein phosphatase non-receptor |
UniProt Gene Name: | PTPN7 |
UniProt Entry Name: | PTN7_HUMAN |
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