Name: Anti-PTPN18 Antibody (CAB8487)
Brand: Cell Biology Antibodies 12
SKU: CAB8487
Availability: OutOfStock

Antibody Name:	Anti-PTPN18 Antibody
Antibody SKU:	CAB8487
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human PTPN18 (NP_001135842.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:	U-251MG, SW620

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human PTPN18 (NP_001135842.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MSRS LDSA RSFL ERLE ARGG REGA VLAG EFSK RCER YWAQ EQEP LQTG LFCI TLIK EKWL NEDI MLRT LKVT FQKE SRSV YQLQ YMSW PDRG VPSS PDHM LAMV EEAR RLQG SGPE PLCV HCSA GCGR TGVL CTVD YVRQ LLLT QMIP PDFS LFDV VLKM RKQR PAAV QTEE QYRF LYHT VAQM FCST LQNA SPHY QNIK ENCA PLYD DA
Gene ID:	26469
Uniprot:	Q99952
Cellular Location:	Cytoplasm, Nucleus
Calculated MW:	38kDa/50kDa
Observed MW:	60kDa

Synonyms:

PTPN18, BDP1, PTP-HSCF

Background:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	BDP1: a member of the non-receptor protein tyrosine phosphatase (PTP) family. Contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines.
UniProt Protein Details:	Protein type:Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor) Chromosomal Location of Human Ortholog: 2q21.1 Molecular Function:protein binding Biological Process: protein amino acid dephosphorylation
NCBI Summary:	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
UniProt Code:	Q99952
NCBI GenInfo Identifier:	215273871
NCBI Gene ID:	26469
NCBI Accession:	Q99952.2
UniProt Secondary Accession:	Q99952,Q53P42, B4E1E6,
UniProt Related Accession:	Q99952
Molecular Weight:	38,476 Da
NCBI Full Name:	Tyrosine-protein phosphatase non-receptor type 18
NCBI Synonym Full Names:	protein tyrosine phosphatase, non-receptor type 18
NCBI Official Symbol:	PTPN18
NCBI Official Synonym Symbols:	BDP1; PTP-HSCF
NCBI Protein Information:	tyrosine-protein phosphatase non-receptor type 18
UniProt Protein Name:	Tyrosine-protein phosphatase non-receptor type 18
UniProt Synonym Protein Names:	Brain-derived phosphatase
Protein Family:	Tyrosine-protein phosphatase non-receptor
UniProt Gene Name:	PTPN18
UniProt Entry Name:	PTN18_HUMAN

Anti-PTPN18 Polyclonal Antibody (CAB8487)

Western blot analysis of extracts of various cell lines, using PTPN18 antibody (CAB8487) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.

Antibodies

PTPN18 Antibody (PACO11588)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)