Epigenetics & Nuclear Signaling Antibodies 1

Anti-PTPN14 Antibody (CAB12093)

(No reviews yet) Write a Review
SKU:
CAB12093
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-PTPN14 Antibody
Antibody SKU:CAB12093
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 650-810 of human PTPN14 (NP_005392.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human
Positive Samples:HeLa, MCF7, A-549, K-562
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 650-810 of human PTPN14 (NP_005392.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VRGM EAMT LKSL HLPM ARRN TLRE QGPP EEGS GSHE VPQL PQYH HKKT FSDA TMLI HSSE SEEE EEEA PESV PQIP MLRE KMEY SAQL QAAL ARIP NKPP PEYP GPRK SVSN GALR QDQA SLPP AMAR ARVL RHGP AKAI SMSR TDPP AVNG ASLG PSIS E
Gene ID:5784
Uniprot:Q15678
Cellular Location:Cytoplasm, Nucleus, cytoskeleton
Calculated MW:135kDa
Observed MW:135kDa
Synonyms:PTPN14, PEZ, PTP36
Background:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia.
UniProt Protein Function:PTPN14: a non-receptor phospho-tyrosine protein phosphatase. Reported to be mutated in a small percentage of human cancers including colorectal cancers and a smaller fraction of lung, breast, and gastric cancers. May play a role in liver metastases and tumour invasion in pancreatic cancer. Contains 1 FERM domain.
UniProt Protein Details:

Protein type:Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.48

Chromosomal Location of Human Ortholog: 1q32.2

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function:protein binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; transcription cofactor activity

Biological Process: lymphangiogenesis; negative regulation of cell proliferation; protein amino acid dephosphorylation; regulation of protein export from nucleus

Disease: Choanal Atresia And Lymphedema

NCBI Summary:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]
UniProt Code:Q15678
NCBI GenInfo Identifier:209572662
NCBI Gene ID:5784
NCBI Accession:Q15678.2
UniProt Secondary Accession:Q15678,Q5VSI0,
UniProt Related Accession:Q15678
Molecular Weight:135,261 Da
NCBI Full Name:Tyrosine-protein phosphatase non-receptor type 14
NCBI Synonym Full Names:protein tyrosine phosphatase, non-receptor type 14
NCBI Official Symbol:PTPN14  
NCBI Official Synonym Symbols:PEZ; PTP36  
NCBI Protein Information:tyrosine-protein phosphatase non-receptor type 14
UniProt Protein Name:Tyrosine-protein phosphatase non-receptor type 14
UniProt Synonym Protein Names:Protein-tyrosine phosphatase pez
Protein Family:Tyrosine-protein phosphatase non-receptor
UniProt Gene Name:PTPN14  
UniProt Entry Name:PTN14_HUMAN
Anti-PTPN14 Antibody (CAB12093)Western blot analysis of extracts of various cell lines, using PTPN14 antibody (CAB12093) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
View AllClose

0 Reviews

View AllClose

Related Products