| UniProt Protein Function: | PTP-PEST: Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2. Interacts with TGFB1I1. Interacts with PSTPIP1. Interacts with PTK2B/PYK2. Interacts with LPXN. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor) Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: cytoplasm; plasma membrane Molecular Function: non-membrane spanning protein tyrosine phosphatase activity; protein binding; SH3 domain binding Biological Process: protein amino acid dephosphorylation |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q05209 |
| NCBI GenInfo Identifier: | 317373522 |
| NCBI Gene ID: | 5782 |
| NCBI Accession: | Q05209.3 |
| UniProt Secondary Accession: | Q05209,Q16130, Q59FD6, Q75MN8, Q86XU4, A4D1C5, B4DKY2 E9PBR5, E9PEH9 |
| UniProt Related Accession: | Q05209 |
| Molecular Weight: | 74,138 Da |
| NCBI Full Name: | Tyrosine-protein phosphatase non-receptor type 12 |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, non-receptor type 12 |
| NCBI Official Symbol: | PTPN12 |
| NCBI Official Synonym Symbols: | PTPG1; PTP-PEST |
| NCBI Protein Information: | tyrosine-protein phosphatase non-receptor type 12 |
| UniProt Protein Name: | Tyrosine-protein phosphatase non-receptor type 12 |
| UniProt Synonym Protein Names: | PTP-PEST; Protein-tyrosine phosphatase G1; PTPG1 |
| Protein Family: | Tyrosine-protein phosphatase non-receptor |
| UniProt Gene Name: | PTPN12 |
| UniProt Entry Name: | PTN12_HUMAN |
