Metabolism Antibodies 3

Anti-PTPMT1 Antibody (CAB8594)

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SKU:
CAB8594
Product Type:
Antibody
Applications:
WB
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-PTPMT1 Antibody
Antibody SKU:CAB8594
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-201 of human PTPMT1 (NP_783859.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-201 of human PTPMT1 (NP_783859.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAT ALLE AGLA RVLF YPTL LYTL FRGK VPGR AHRD WYHR IDPT VLLG ALPL RSLT RQLV QDEN VRGV ITMN EEYE TRFL CNSS QEWK RLGV EQLR LSTV DMTG IPTL DNLQ KGVQ FALK YQSL GQCV YVHC KAGR SRSA TMVA AYLI QVHK WSPE EAVR AIAK IRSY IHIR PGQL DVLK EFHK QITA RATK DGTF VISK T
Gene ID:114971
Uniprot:Q8WUK0
Cellular Location:Mitochondrion inner membrane
Calculated MW:15kDa/16kDa/22kDa
Observed MW:23kDa
Synonyms:PTPMT1, DUSP23, MOSP, PLIP, PNAS-129
Background:
UniProt Protein Function:PTPMT1: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.1.3.16; EC 3.1.3.27; EC 3.1.3.48; Mitochondrial; Phosphatase, lipid; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: mitochondrion; nucleus

Molecular Function:phosphatidylglycerophosphatase activity; phosphoinositide 5-phosphatase activity; protein binding

Biological Process: cardiolipin biosynthetic process

UniProt Code:Q8WUK0
NCBI GenInfo Identifier:221218988
NCBI Gene ID:114971
NCBI Accession:NP_001137456.1
UniProt Secondary Accession:Q8WUK0,Q7Z557, Q96CR2, Q9BXV8, E9PAT8,
UniProt Related Accession:Q8WUK0
Molecular Weight:35.9kD
NCBI Full Name:phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform 2
NCBI Synonym Full Names:protein tyrosine phosphatase, mitochondrial 1
NCBI Official Symbol:PTPMT1  
NCBI Official Synonym Symbols:MOSP; PLIP; DUSP23; PNAS-129  
NCBI Protein Information:phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
UniProt Protein Name:Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
UniProt Synonym Protein Names:PTEN-like phosphatase; Phosphoinositide lipid phosphatase; Protein-tyrosine phosphatase mitochondrial 1 (EC:3.1.3.16, EC:3.1.3.48)
Protein Family:Phosphatidylglycerophosphatase and protein-tyrosine phosphatase
UniProt Gene Name:PTPMT1  
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system_update_altDatasheetHuman PTPMT1 Recombinant Protein PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively