Name: Anti-PTP4A1 Antibody (CAB12360)
Brand: Cell Cycle Antibodies 1
SKU: CAB12360
Availability: OutOfStock

Antibody Name:	Anti-PTP4A1 Antibody
Antibody SKU:	CAB12360
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-173 of human PTP4A1 (NP_003454.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	A-549, Mouse liver, Rat skeletal muscle, Rat liver

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-173 of human PTP4A1 (NP_003454.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MARM NRPA PVEV TYKN MRFL ITHN PTNA TLNK FIEE LKKY GVTT IVRV CEAT YDTT LVEK EGIH VLDW PFDD GAPP SNQI VDDW LSLV KIKF REEP GCCI AVHC VAGL GRAP VLVA LALI EGGM KYED AVQF IRQK RRGA FNSK QLLY LEKY RPKM RLRF KDSN GHRN NCCI Q
Gene ID:	7803
Uniprot:	Q93096
Cellular Location:	Cell membrane, Cytoplasm, Early endosome, Endoplasmic reticulum, cytoskeleton, spindle
Calculated MW:	19kDa
Observed MW:	20kDa

Synonyms:

PTP4A1, HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX1

Background:

This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X.

UniProt Protein Function:	PTP4A1: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. Belongs to the protein-tyrosine phosphatase family.
UniProt Protein Details:	Protein type:Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor) Chromosomal Location of Human Ortholog: 6q12 Cellular Component: cytoplasm; internal side of plasma membrane; nucleus Molecular Function:protein tyrosine phosphatase activity Biological Process: positive regulation of cell migration
NCBI Summary:	This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]
UniProt Code:	Q93096
NCBI GenInfo Identifier:	68566217
NCBI Gene ID:	7803
NCBI Accession:	Q93096.2
UniProt Secondary Accession:	Q93096,O00648, Q49A54, B2R6C8,
UniProt Related Accession:	Q93096
Molecular Weight:	19,815 Da
NCBI Full Name:	Protein tyrosine phosphatase type IVA 1
NCBI Synonym Full Names:	protein tyrosine phosphatase type IVA, member 1
NCBI Official Symbol:	PTP4A1
NCBI Official Synonym Symbols:	HH72; PRL1; PRL-1; PTPCAAX1; PTP(CAAX1)
NCBI Protein Information:	protein tyrosine phosphatase type IVA 1
UniProt Protein Name:	Protein tyrosine phosphatase type IVA 1
UniProt Synonym Protein Names:	PTP(CAAXI); Protein-tyrosine phosphatase 4a1; Protein-tyrosine phosphatase of regenerating liver 1; PRL-1
Protein Family:	Protein tyrosine phosphatase
UniProt Gene Name:	PTP4A1
UniProt Entry Name:	TP4A1_HUMAN

Western blot analysis of extracts of various cell lines, using PTP4A1 antibody (CAB12360) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

Antibodies

PTP4A1 Antibody (PACO11583)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)