Epigenetics & Nuclear Signaling Antibodies 2
Anti-PTOV1 Antibody (CAB16126)
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- SKU:
- CAB16126
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-PTOV1 Antibody |
| Antibody SKU: | CAB16126 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PTOV1 (NP_001292037.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HT-29 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PTOV1 (NP_001292037.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MRSP AVPT PARG QLGV AFVL LPPH SEGA RVFG ALGP IGPS SPGL TLGG LAVS EHRL SNKL LAWS GVLE WQEK RRPY SDST AKLK RTLP CQAY VNQG ENLE |
| Gene ID: | 53635 |
| Uniprot: | Q86YD1 |
| Cellular Location: | Cell membrane, Cytoplasm, Nucleus, perinuclear region |
| Calculated MW: | 26kDa/42kDa/46kDa |
| Observed MW: | 47kDa |
| Synonyms: | PTOV1, ACID2, PTOV-1 |
| Background: | This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | PTOV1: May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: nucleus |
| NCBI Summary: | This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015] |
| UniProt Code: | Q86YD1 |
| NCBI GenInfo Identifier: | 74762466 |
| NCBI Gene ID: | 53635 |
| NCBI Accession: | Q86YD1.1 |
| UniProt Secondary Accession: | Q86YD1,Q6UXX7, Q96BU3, Q9HBN4, Q9NYL1, |
| UniProt Related Accession: | Q86YD1 |
| Molecular Weight: | 26,145 Da |
| NCBI Full Name: | Prostate tumor-overexpressed gene 1 protein |
| NCBI Synonym Full Names: | prostate tumor overexpressed 1 |
| NCBI Official Symbol: | PTOV1 |
| NCBI Official Synonym Symbols: | ACID2; PTOV-1 |
| NCBI Protein Information: | prostate tumor-overexpressed gene 1 protein |
| UniProt Protein Name: | Prostate tumor-overexpressed gene 1 protein |
| UniProt Synonym Protein Names: | Activator interaction domain-containing protein 2 |
| Protein Family: | Prostate tumor-overexpressed gene 1 protein |
| UniProt Gene Name: | PTOV1 |
| UniProt Entry Name: | PTOV1_HUMAN |
 | Western blot analysis of extracts of HT-29 cells, using PTOV1 antibody (CAB16126) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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