Epigenetics & Nuclear Signaling Antibodies 2

Anti-PTOV1 Antibody (CAB16126)

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SKU:
CAB16126
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-PTOV1 Antibody
Antibody SKU:CAB16126
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PTOV1 (NP_001292037.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HT-29
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PTOV1 (NP_001292037.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MRSP AVPT PARG QLGV AFVL LPPH SEGA RVFG ALGP IGPS SPGL TLGG LAVS EHRL SNKL LAWS GVLE WQEK RRPY SDST AKLK RTLP CQAY VNQG ENLE
Gene ID:53635
Uniprot:Q86YD1
Cellular Location:Cell membrane, Cytoplasm, Nucleus, perinuclear region
Calculated MW:26kDa/42kDa/46kDa
Observed MW:47kDa
Synonyms:PTOV1, ACID2, PTOV-1
Background:This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants.
UniProt Protein Function:PTOV1: May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: nucleus

NCBI Summary:This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
UniProt Code:Q86YD1
NCBI GenInfo Identifier:74762466
NCBI Gene ID:53635
NCBI Accession:Q86YD1.1
UniProt Secondary Accession:Q86YD1,Q6UXX7, Q96BU3, Q9HBN4, Q9NYL1,
UniProt Related Accession:Q86YD1
Molecular Weight:26,145 Da
NCBI Full Name:Prostate tumor-overexpressed gene 1 protein
NCBI Synonym Full Names:prostate tumor overexpressed 1
NCBI Official Symbol:PTOV1  
NCBI Official Synonym Symbols:ACID2; PTOV-1  
NCBI Protein Information:prostate tumor-overexpressed gene 1 protein
UniProt Protein Name:Prostate tumor-overexpressed gene 1 protein
UniProt Synonym Protein Names:Activator interaction domain-containing protein 2
Protein Family:Prostate tumor-overexpressed gene 1 protein
UniProt Gene Name:PTOV1  
UniProt Entry Name:PTOV1_HUMAN
Anti-PTOV1 Antibody (CAB16126)Western blot analysis of extracts of HT-29 cells, using PTOV1 antibody (CAB16126) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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