Cell Biology Antibodies 12
Anti-PTK7 Antibody (CAB9839)
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- SKU:
- CAB9839
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PTK7 Antibody |
| Antibody SKU: | CAB9839 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 811-1070 of human PTK7 (NP_002812.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NCI-H460, HepG2, SKOV3, Jurkat, Mouse lung, Mouse liver, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 811-1070 of human PTK7 (NP_002812.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FLAK AQGL EEGV AETL VLVK SLQS KDEQ QQLD FRRE LEMF GKLN HANV VRLL GLCR EAEP HYMV LEYV DLGD LKQF LRIS KSKD EKLK SQPL STKQ KVAL CTQV ALGM EHLS NNRF VHKD LAAR NCLV SAQR QVKV SALG LSKD VYNS EYYH FRQA WVPL RWMS PEAI LEGD FSTK SDVW AFGV LMWE VFTH GEMP HGGQ ADDE VLAD LQAG KARL PQPE GCPS KLYR LMQR CWAL SPKD RPSF SEIA SALG DSTV DSKP |
| Gene ID: | 5754 |
| Uniprot: | Q13308 |
| Cellular Location: | Cell junction, Membrane, Single-pass type I membrane protein |
| Calculated MW: | 89kDa/103kDa/112kDa/113kDa/118kDa/119kDa |
| Observed MW: | 80kDa |
| Synonyms: | PTK7, CCK-4, CCK4 |
| Background: | This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. |
| NCBI Summary: | This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q13308 |
| NCBI GenInfo Identifier: | 116242736 |
| NCBI Gene ID: | 5754 |
| NCBI Accession: | Q13308.2 |
| UniProt Secondary Accession: | Q13308,Q13417, Q5T650, Q6IQ54, Q8NFA5, Q8NFA6, Q8NFA7 Q8NFA8, A8K974, B7Z477, E9PFZ5, |
| UniProt Related Accession: | Q13308 |
| Molecular Weight: | 119,197 Da |
| NCBI Full Name: | Inactive tyrosine-protein kinase 7 |
| NCBI Synonym Full Names: | protein tyrosine kinase 7 (inactive) |
| NCBI Official Symbol: | PTK7 |
| NCBI Official Synonym Symbols: | CCK4; CCK-4 |
| NCBI Protein Information: | inactive tyrosine-protein kinase 7 |
| UniProt Protein Name: | Inactive tyrosine-protein kinase 7 |
| UniProt Synonym Protein Names: | Colon carcinoma kinase 4; CCK-4; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7 |
| Protein Family: | Inactive tyrosine-protein kinase |
| UniProt Gene Name: | PTK7 |
| UniProt Entry Name: | PTK7_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PTK7 antibody (CAB9839) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
 | Immunohistochemistry of paraffin-embedded mouse brain using PTK7 antibody (CAB9839) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human prostate using PTK7 antibody (CAB9839) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using PTK7 antibody (CAB9839) at dilution of 1:100 (40x lens). |
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