Cell Biology Antibodies 8

Anti-PTHLH Antibody (CAB3183)

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SKU:
CAB3183
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PTHLH Antibody
Antibody SKU:CAB3183
Antibody Size:20uL, 100uL
Application:WB IHC FC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide of human PTHLH
Application:WB IHC FC
Recommended Dilution:WB 1:500 - 1:1000 IHC 1:50 - 1:100 FC 1:20 - 1:50
Reactivity:Human, Mouse
Positive Samples:Mouse spleen
Immunogen:A synthetic peptide of human PTHLH
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5744
Uniprot:P12272
Cellular Location:Cytoplasm, Nucleus, Secreted
Calculated MW:19kDa/20kDa/23kDa
Observed MW:26kDa
Synonyms:PTHLH, BDE2, HHM, PLP, PTHR, PTHRP
Background:The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone.
UniProt Protein Function:PTHrP: a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Three alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12p12.1-p11.2

Cellular Component: nucleoplasm; Golgi apparatus; extracellular space; cytoplasm; extracellular region

Molecular Function:peptide hormone receptor binding; hormone activity

Biological Process: epidermis development; negative regulation of transcription factor activity; negative regulation of chondrocyte differentiation; female pregnancy; G-protein signaling, adenylate cyclase activating pathway; osteoblast development; negative regulation of cell proliferation; cAMP metabolic process; epithelial cell differentiation; cell-cell signaling; regulation of gene expression; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; protein processing; skeletal development; surfactant homeostasis; alveolus development; endochondral ossification; endoderm development

Disease: Brachydactyly, Type E2

NCBI Summary:The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013]
UniProt Code:P12272
NCBI GenInfo Identifier:131542
NCBI Gene ID:5744
NCBI Accession:P12272.1
UniProt Secondary Accession:P12272,Q15251, Q6FH74,
UniProt Related Accession:P12272
Molecular Weight:Calculated MW: 19kDa/20kDa/23kDa
NCBI Full Name:Parathyroid hormone-related protein
NCBI Synonym Full Names:parathyroid hormone-like hormone
NCBI Official Symbol:PTHLH  
NCBI Official Synonym Symbols:HHM; PLP; BDE2; PTHR; PTHRP  
NCBI Protein Information:parathyroid hormone-related protein; PTH-rP; osteostatin; PTH-related protein; parathyroid hormone-like related protein; parathyroid hormone-like hormone preproprotein
UniProt Protein Name:Parathyroid hormone-related protein
UniProt Synonym Protein Names:Parathyroid hormone-like protein; PLP
Protein Family:Parathyroid hormone-related protein
UniProt Gene Name:PTHLH  
UniProt Entry Name:PTHR_HUMAN
Anti-PTHLH Antibody (CAB3183)Western blot analysis of extracts of mouse spleen, using PTHLH antibody (CAB3183). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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