Cell Biology Antibodies 7
Anti-PTHLH Antibody (CAB1654)
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- SKU:
- CAB1654
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PTHLH Antibody |
| Antibody SKU: | CAB1654 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-175 of human PTHLH (NP_945315.1). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-175 of human PTHLH (NP_945315.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RSVE GLSR RLKR AVSE HQLL HDKG KSIQ DLRR RFFL HHLI AEIH TAEI RATS EVSP NSKP SPNT KNHP VRFG SDDE GRYL TQET NKVE TYKE QPLK TPGK KKKG KPGK RKEQ EKKK RRTR SAWL DSGV TGSG LEGD HLSD TSTT SLEL DSR |
| Gene ID: | 5744 |
| Uniprot: | P12272 |
| Cellular Location: | Cytoplasm, Nucleus, Secreted |
| Calculated MW: | 19kDa/20kDa/23kDa |
| Observed MW: |
| Synonyms: | PTHLH, BDE2, HHM, PLP, PTHR, PTHRP |
| Background: | The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. |
| UniProt Protein Function: | PTHrP: a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Three alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 12p12.1-p11.2 Cellular Component: nucleoplasm; Golgi apparatus; extracellular space; cytoplasm; extracellular region Molecular Function:peptide hormone receptor binding; hormone activity Biological Process: epidermis development; negative regulation of transcription factor activity; negative regulation of chondrocyte differentiation; female pregnancy; G-protein signaling, adenylate cyclase activating pathway; osteoblast development; negative regulation of cell proliferation; cAMP metabolic process; epithelial cell differentiation; cell-cell signaling; regulation of gene expression; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; protein processing; skeletal development; surfactant homeostasis; alveolus development; endochondral ossification; endoderm development Disease: Brachydactyly, Type E2 |
| NCBI Summary: | The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013] |
| UniProt Code: | P12272 |
| NCBI GenInfo Identifier: | 131542 |
| NCBI Gene ID: | 5744 |
| NCBI Accession: | P12272.1 |
| UniProt Secondary Accession: | P12272,Q15251, Q6FH74, |
| UniProt Related Accession: | P12272 |
| Molecular Weight: | Calculated MW: 19kDa/20kDa/23kDa |
| NCBI Full Name: | Parathyroid hormone-related protein |
| NCBI Synonym Full Names: | parathyroid hormone-like hormone |
| NCBI Official Symbol: | PTHLH |
| NCBI Official Synonym Symbols: | HHM; PLP; BDE2; PTHR; PTHRP |
| NCBI Protein Information: | parathyroid hormone-related protein; PTH-rP; osteostatin; PTH-related protein; parathyroid hormone-like related protein; parathyroid hormone-like hormone preproprotein |
| UniProt Protein Name: | Parathyroid hormone-related protein |
| UniProt Synonym Protein Names: | Parathyroid hormone-like protein; PLP |
| Protein Family: | Parathyroid hormone-related protein |
| UniProt Gene Name: | PTHLH |
| UniProt Entry Name: | PTHR_HUMAN |
 | Immunohistochemistry of paraffin-embedded rat brain using PTHLH antibody (CAB1654) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using PTHLH antibody (CAB1654) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PTHLH antibody (CAB1654) at dilution of 1:200 (40x lens). |
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