Neuroscience

Anti-PTH2R Antibody (CAB4058)

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SKU:
CAB4058
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Neuroscience

Description

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Antibody Name:Anti-PTH2R Antibody
Antibody SKU:CAB4058
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-145 of human PTH2R (NP_005039.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:BxPC-3, LO2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-145 of human PTH2R (NP_005039.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DSDG TITI EEQI VLVL KAKV QCEL NITA QLQE GEGN CFPE WDGL ICWP RGTV GKIS AVPC PPYI YDFN HKGV AFRH CNPN GTWD FMHS LNKT WANY SDCL RFLQ PDIS IGKQ EFFE RLY
Gene ID:5746
Uniprot:P49190
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:62kDa
Observed MW:62kDa
Synonyms:PTH2R, PTHR2
Background:The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:PTH2R: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor. Belongs to the G-protein coupled receptor 2 family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 2; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:parathyroid hormone receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway

NCBI Summary:The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
UniProt Code:P49190
NCBI GenInfo Identifier:1346906
NCBI Gene ID:5746
NCBI Accession:P49190.1
UniProt Secondary Accession:P49190,Q8N429,
UniProt Related Accession:P49190
Molecular Weight:550
NCBI Full Name:Parathyroid hormone 2 receptor
NCBI Synonym Full Names:parathyroid hormone 2 receptor
NCBI Official Symbol:PTH2R  
NCBI Official Synonym Symbols:PTHR2  
NCBI Protein Information:parathyroid hormone 2 receptor; PTH2 receptor; parathyroid hormone receptor 2
UniProt Protein Name:Parathyroid hormone 2 receptor
Protein Family:Parathyroid hormone 2 receptor
UniProt Gene Name:PTH2R  
UniProt Entry Name:PTH2R_HUMAN
Anti-PTH2R Antibody (CAB4058)Western blot analysis of extracts of various cell lines, using PTH2R antibody (CAB4058) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.
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