Neuroscience
Anti-PTH2R Antibody (CAB4058)
- SKU:
- CAB4058
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Neuroscience
Description
| Antibody Name: | Anti-PTH2R Antibody |
| Antibody SKU: | CAB4058 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-145 of human PTH2R (NP_005039.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | BxPC-3, LO2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-145 of human PTH2R (NP_005039.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DSDG TITI EEQI VLVL KAKV QCEL NITA QLQE GEGN CFPE WDGL ICWP RGTV GKIS AVPC PPYI YDFN HKGV AFRH CNPN GTWD FMHS LNKT WANY SDCL RFLQ PDIS IGKQ EFFE RLY |
| Gene ID: | 5746 |
| Uniprot: | P49190 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 62kDa |
| Observed MW: | 62kDa |
| Synonyms: | PTH2R, PTHR2 |
| Background: | The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | PTH2R: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor. Belongs to the G-protein coupled receptor 2 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 2; Membrane protein, integral Chromosomal Location of Human Ortholog: 2q33 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:parathyroid hormone receptor activity Biological Process: G-protein coupled receptor protein signaling pathway |
| NCBI Summary: | The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
| UniProt Code: | P49190 |
| NCBI GenInfo Identifier: | 1346906 |
| NCBI Gene ID: | 5746 |
| NCBI Accession: | P49190.1 |
| UniProt Secondary Accession: | P49190,Q8N429, |
| UniProt Related Accession: | P49190 |
| Molecular Weight: | 550 |
| NCBI Full Name: | Parathyroid hormone 2 receptor |
| NCBI Synonym Full Names: | parathyroid hormone 2 receptor |
| NCBI Official Symbol: | PTH2R |
| NCBI Official Synonym Symbols: | PTHR2 |
| NCBI Protein Information: | parathyroid hormone 2 receptor; PTH2 receptor; parathyroid hormone receptor 2 |
| UniProt Protein Name: | Parathyroid hormone 2 receptor |
| Protein Family: | Parathyroid hormone 2 receptor |
| UniProt Gene Name: | PTH2R |
| UniProt Entry Name: | PTH2R_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PTH2R antibody (CAB4058) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |
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