Immunology Antibodies 2

Anti-PTGR1 Antibody (CAB4521)

(No reviews yet) Write a Review
SKU:
CAB4521
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PTGR1
Synonyms:
LTB4DH
Synonyms:
PGR1
Synonyms:
ZADH3
Research Area:
Immunology

Description

Product Name:PTGR1 Rabbit pAb
Product Code:CAB4521
Size:20uL, 50uL, 100uL
Synonyms:PTGR1, LTB4DH, PGR1, ZADH3
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human PTGR1 (NP_036344.2).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, Mouse heart, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human PTGR1 (NP_036344.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVRT KTWT LKKH FVGY PTNS DFEL KTAE LPPL KNGE VLLE ALFL TVDP YMRV AAKR LKEG DTMM GQQV AKVV ESKN VALP KGTI VLAS PGWT THSI SDGK DLEK LLTE WPDT IPL
Gene ID:22949
Uniprot:Q14914
Cellular Location:Cytoplasm
Calculated MW:32kDa/35kDa
Observed MW:36kDa
UniProt Protein Function:LTB4DH: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. Belongs to the NADP-dependent oxidoreductase L4BD family.
UniProt Protein Details:

Protein type:EC 1.3.1.48; Oxidoreductase; EC 1.3.1.74

Chromosomal Location of Human Ortholog: 9q31.3

Cellular Component: cytoplasm

Molecular Function:15-oxoprostaglandin 13-oxidase activity; zinc ion binding; 2-alkenal reductase activity

Biological Process: response to toxin; cyclooxygenase pathway; arachidonic acid metabolic process; leukotriene metabolic process

NCBI Summary:This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
UniProt Code:Q14914
NCBI GenInfo Identifier:23503081
NCBI Gene ID:22949
NCBI Accession:Q14914.2
UniProt Secondary Accession:Q14914,Q8IYQ0, Q9H1X6, A8K0N2, B4DPK3, F5GY50,
UniProt Related Accession:Q14914
Molecular Weight:329
NCBI Full Name:Prostaglandin reductase 1
NCBI Synonym Full Names:prostaglandin reductase 1
NCBI Official Symbol:PTGR1  
NCBI Official Synonym Symbols:PGR1; ZADH3; LTB4DH  
NCBI Protein Information:prostaglandin reductase 1; PRG-1; 15-oxoprostaglandin 13-reductase; leukotriene B4 12-hydroxydehydrogenase; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; zinc binding alcohol dehydrogenase domain containing 3
UniProt Protein Name:Prostaglandin reductase 1
UniProt Synonym Protein Names:15-oxoprostaglandin 13-reductase (EC:1.3.1.48); NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC:1.3.1.74)
Protein Family:Prostaglandin reductase
UniProt Gene Name:PTGR1  
UniProt Entry Name:PTGR1_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products