Cell Biology Antibodies 7
Anti-PTGIR Antibody (CAB1849)
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- SKU:
- CAB1849
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PTGIR Antibody |
| Antibody SKU: | CAB1849 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 207-386 of human PTGIR (NP_000951.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse eye, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 207-386 of human PTGIR (NP_000951.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TLSL CRMY RQQK RHQG SLGP RPRT GEDE VDHL ILLA LMTV VMAV CSLP LTIR CFTQ AVAP DSSS EMGD LLAF RFYA FNPI LDPW VFIL FRKA VFQR LKLW VCCL CLGP AHGD SQTP LSQL ASGR RDPR APSA PVGK EGSC VPLS AWGE GQVE PLPP TQQS SGSA VGTS SKAE ASVA CSLC |
| Gene ID: | 5739 |
| Uniprot: | P43119 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 40kDa |
| Observed MW: | 41kDa |
| Synonyms: | PTGIR, IP, PRIPR |
| Background: | The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. |
| UniProt Protein Function: | PTGIR: Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: integral to plasma membrane; plasma membrane; cytosol Molecular Function:G-protein coupled receptor activity; guanyl-nucleotide exchange factor activity Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; cell-cell signaling; negative regulation of smooth muscle cell proliferation; positive regulation of cAMP biosynthetic process; response to lipopolysaccharide; blood coagulation; G-protein signaling, adenylate cyclase activating pathway; positive regulation of GTPase activity |
| NCBI Summary: | The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P43119 |
| NCBI GenInfo Identifier: | 1172500 |
| NCBI Gene ID: | 5739 |
| NCBI Accession: | P43119.1 |
| UniProt Related Accession: | P43119 |
| Molecular Weight: | Calculated: 40kDaObserved: 41kDa |
| NCBI Full Name: | Prostacyclin receptor |
| NCBI Synonym Full Names: | prostaglandin I2 (prostacyclin) receptor (IP) |
| NCBI Official Symbol: | PTGIR |
| NCBI Official Synonym Symbols: | IP; PRIPR |
| NCBI Protein Information: | prostacyclin receptor; PGI receptor; PGI2 receptor; prostanoid IP receptor; prostaglandin I2 receptor |
| UniProt Protein Name: | Prostacyclin receptor |
| UniProt Synonym Protein Names: | Prostaglandin I2 receptor; PGI receptor; PGI2 receptor; Prostanoid IP receptor |
| Protein Family: | Prostacyclin receptor |
| UniProt Gene Name: | PTGIR |
| UniProt Entry Name: | PI2R_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PTGIR antibody (CAB1849) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PTGIR antibody (CAB1849) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using PTGIR antibody (CAB1849) at dilution of 1:200 (40x lens). |
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