Metabolism Antibodies 2
Anti-PTGES3 Antibody (CAB5325)
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- SKU:
- CAB5325
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-PTGES3 Antibody |
| Antibody SKU: | CAB5325 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PTGES3 (NP_006592.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Jurkat, Mouse testis, Rat testis |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PTGES3 (NP_006592.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MQPA SAKW YDRR DYVF IEFC VEDS KDVN VNFE KSKL TFSC LGGS DNFK HLNE IDLF HCID PNDS KHKR TDRS ILCC LRKG ESGQ SWPR LTKE RAKL NWLS |
| Gene ID: | 10728 |
| Uniprot: | Q15185 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 14kDa/16kDa/18kDa |
| Observed MW: | 23kDa |
| Synonyms: | PTGES3, P23, TEBP, cPGES |
| Background: | This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. |
| UniProt Protein Function: | TEBP: Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Belongs to the p23/wos2 family. |
| UniProt Protein Details: | Protein type:Transferase; Chaperone; Nuclear receptor co-regulator; EC 5.3.99.3; Isomerase Chromosomal Location of Human Ortholog: 12q13.3|12 Cellular Component: chromosome, telomeric region; cytoplasm; cytosol; nucleoplasm; nucleus; telomerase holoenzyme complex Molecular Function:prostaglandin-E synthase activity; protein binding; telomerase activity; unfolded protein binding Biological Process: arachidonic acid metabolic process; cyclooxygenase pathway; prostaglandin biosynthetic process; RNA-dependent DNA replication; signal transduction; telomere maintenance |
| NCBI Summary: | This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016] |
| UniProt Code: | Q15185 |
| NCBI GenInfo Identifier: | 8928247 |
| NCBI Gene ID: | 10728 |
| NCBI Accession: | Q15185.1 |
| UniProt Secondary Accession: | Q15185,Q8WU70, A8K7D0, B4DHP2, B4DP11, B4DP21, |
| UniProt Related Accession: | Q15185 |
| Molecular Weight: | 16,476 Da |
| NCBI Full Name: | Prostaglandin E synthase 3 |
| NCBI Synonym Full Names: | prostaglandin E synthase 3 |
| NCBI Official Symbol: | PTGES3 |
| NCBI Official Synonym Symbols: | P23; TEBP; cPGES |
| NCBI Protein Information: | prostaglandin E synthase 3 |
| UniProt Protein Name: | Prostaglandin E synthase 3 |
| UniProt Synonym Protein Names: | Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23 |
| UniProt Gene Name: | PTGES3 |
| UniProt Entry Name: | TEBP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PTGES3 antibody (CAB5325) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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