Cell Biology Antibodies 15
Anti-PTGES Antibody (CAB18632)
- SKU:
- CAB18632
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PTGES Antibody |
| Antibody SKU: | CAB18632 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human PTGES. |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, Mouse lung, Rat lung |
| Immunogen: | A synthetic peptide of human PTGES. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9536 |
| Uniprot: | O14684 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 17kDa |
 | Western blot - PTGES Rabbit pAb (CAB18632) |
| Synonyms: | |
| Background: |
| UniProt Protein Function: | PTGES: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Belongs to the MAPEG family. |
| UniProt Protein Details: | Protein type:EC 5.3.99.3; Nuclear envelope; Isomerase; Membrane protein, multi-pass; Membrane protein, integral; Lipid Metabolism - arachidonic acid Chromosomal Location of Human Ortholog: 9q34.3 Cellular Component: endoplasmic reticulum membrane; membrane; nuclear envelope lumen; perinuclear region of cytoplasm; integral to membrane Molecular Function:glutathione binding; prostaglandin-E synthase activity Biological Process: chronic inflammatory response; response to retinoic acid; cyclooxygenase pathway; response to lipopolysaccharide; prostaglandin biosynthetic process; signal transduction; response to organic cyclic substance; prostaglandin metabolic process; negative regulation of cell proliferation; response to cytokine stimulus; arachidonic acid metabolic process; response to calcium ion; acute inflammatory response |
| NCBI Summary: | The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14684 |
| NCBI GenInfo Identifier: | 4758910 |
| NCBI Gene ID: | 9536 |
| NCBI Accession: | NP_004869.1 |
| UniProt Secondary Accession: | O14684,O14900, Q5SZC0, |
| UniProt Related Accession: | O14684 |
| Molecular Weight: | 17kd |
| NCBI Full Name: | prostaglandin E synthase |
| NCBI Synonym Full Names: | prostaglandin E synthase |
| NCBI Official Symbol: | PTGES |
| NCBI Official Synonym Symbols: | PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1 |
| NCBI Protein Information: | prostaglandin E synthase |
| UniProt Protein Name: | Prostaglandin E synthase |
| UniProt Synonym Protein Names: | Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein |
| UniProt Gene Name: | PTGES |
| UniProt Entry Name: | PTGES_HUMAN |
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