Name: Anti-PTGER1 Antibody (CAB2913)
Brand: Cell Biology Antibodies 8
SKU: CAB2913
Availability: OutOfStock

Antibody Name:	Anti-PTGER1 Antibody
Antibody SKU:	CAB2913
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	A synthetic peptide of human PTGER1

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse
Positive Samples:	Mouse kidney

Immunogen:	A synthetic peptide of human PTGER1
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	5731
Uniprot:	P34995
Cellular Location:	Cell membrane, Multi-pass membrane protein
Calculated MW:	41kDa
Observed MW:	42kDa

Synonyms:

PTGER1, EP1

Background:

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.

UniProt Protein Function:	PTGER1: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:	Protein type:Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 19p13.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:prostaglandin E receptor activity Biological Process: G-protein coupled receptor protein signaling pathway; response to lipopolysaccharide
NCBI Summary:	The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008]
UniProt Code:	P34995
NCBI GenInfo Identifier:	83287886
NCBI Gene ID:	5731
NCBI Accession:	P34995.3
UniProt Secondary Accession:	P34995,Q5U5U4, Q86UH3, Q86VB5, Q8NHB2,
UniProt Related Accession:	P34995
Molecular Weight:	402
NCBI Full Name:	Prostaglandin E2 receptor EP1 subtype
NCBI Synonym Full Names:	prostaglandin E receptor 1 (subtype EP1), 42kDa
NCBI Official Symbol:	PTGER1
NCBI Official Synonym Symbols:	EP1
NCBI Protein Information:	prostaglandin E2 receptor EP1 subtype; prostanoid EP1 receptor; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PGE2 receptor EP1 subtype; prostaglandin E receptor 1, subtype EP1; prostaglandin E receptor 1 (subtype EP1), 42kD
UniProt Protein Name:	Prostaglandin E2 receptor EP1 subtype
UniProt Synonym Protein Names:	Prostanoid EP1 receptor
Protein Family:	Epidermis-specific secreted glycoprotein
UniProt Gene Name:	PTGER1
UniProt Entry Name:	PE2R1_HUMAN

Western blot analysis of extracts of mouse kidney, using PTGER1 antibody (CAB2913) at 1:400 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021).

Antibodies

Anti-PTGER1 Antibody (CAB12310)

PTGER1 Antibody (PACO02123)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)