Cell Biology Antibodies 2
Anti-PTGER1 Antibody (CAB12310)
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- SKU:
- CAB12310
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PTGER1 Antibody |
| Antibody SKU: | CAB12310 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human PTGER1 (NP_000946.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse pancreas |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human PTGER1 (NP_000946.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VGIM VVSC ICWS PMLV LVAL AVGG WSST SLQR PLFL AVRL ASWN QILD PWVY ILLR QAVL RQLL RLLP PRAG AKGG PAGL GLTP SAWE ASSL RSSR HSGL S |
| Gene ID: | 5731 |
| Uniprot: | P34995 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 41kDa |
| Observed MW: | 42kDa |
| Synonyms: | PTGER1, EP1 |
| Background: | The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. |
| UniProt Protein Function: | PTGER1: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 19p13.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:prostaglandin E receptor activity Biological Process: G-protein coupled receptor protein signaling pathway; response to lipopolysaccharide |
| NCBI Summary: | The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P34995 |
| NCBI GenInfo Identifier: | 83287886 |
| NCBI Gene ID: | 5731 |
| NCBI Accession: | P34995.3 |
| UniProt Secondary Accession: | P34995,Q5U5U4, Q86UH3, Q86VB5, Q8NHB2, |
| UniProt Related Accession: | P34995 |
| Molecular Weight: | 402 |
| NCBI Full Name: | Prostaglandin E2 receptor EP1 subtype |
| NCBI Synonym Full Names: | prostaglandin E receptor 1 (subtype EP1), 42kDa |
| NCBI Official Symbol: | PTGER1 |
| NCBI Official Synonym Symbols: | EP1 |
| NCBI Protein Information: | prostaglandin E2 receptor EP1 subtype; prostanoid EP1 receptor; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PGE2 receptor EP1 subtype; prostaglandin E receptor 1, subtype EP1; prostaglandin E receptor 1 (subtype EP1), 42kD |
| UniProt Protein Name: | Prostaglandin E2 receptor EP1 subtype |
| UniProt Synonym Protein Names: | Prostanoid EP1 receptor |
| Protein Family: | Epidermis-specific secreted glycoprotein |
| UniProt Gene Name: | PTGER1 |
| UniProt Entry Name: | PE2R1_HUMAN |
 | Western blot analysis of extracts of mouse pancreas, using PTGER1 antibody (CAB12310) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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