Cell Biology Antibodies 3
Anti-PTGDR Antibody (CAB12877)
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- SKU:
- CAB12877
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PTGDR Antibody |
| Antibody SKU: | CAB12877 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-359 of human PTGDR (NP_000944.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | NIH/3T3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-359 of human PTGDR (NP_000944.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GAMR NLYA MHRR LQRH PRSC TRDC AEPR ADGR EASP QPLE ELDH LLLL ALMT VLFT MCSL PVIY RAYY GAFK DVKE KNRT SEEA EDLR ALRF LSVI SIVD PWIF IIFR SPVF RIFF HKIF IRPL RYRS RCSN STNM ESSL |
| Gene ID: | 5729 |
| Uniprot: | Q13258 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 32kDa/40kDa |
| Observed MW: | 43kDa |
| Synonyms: | PTGDR, AS1, ASRT1, DP, DP1, PTGDR1 |
| Background: | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | PTGDR: Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate. Genetic variations in PTGDR are associated with susceptibility to asthma-related traits type 1 (ASRT1). Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 14q22.1 Cellular Component: plasma membrane Molecular Function:prostaglandin D receptor activity; prostaglandin E receptor activity; protein binding Disease: Asthma-related Traits, Susceptibility To, 1 |
| NCBI Summary: | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q13258 |
| NCBI GenInfo Identifier: | 2495009 |
| NCBI Gene ID: | 5729 |
| NCBI Accession: | Q13258.2 |
| UniProt Secondary Accession: | Q13258,Q13250, Q13251, Q1ZZ52, G3V5L3, |
| UniProt Related Accession: | Q13258 |
| Molecular Weight: | Calculated MW: 32kDa/40kDaObserved MW: 43kDa |
| NCBI Full Name: | Prostaglandin D2 receptor |
| NCBI Synonym Full Names: | prostaglandin D2 receptor |
| NCBI Official Symbol: | PTGDR |
| NCBI Official Synonym Symbols: | DP; AS1; DP1; ASRT1; PTGDR1 |
| NCBI Protein Information: | prostaglandin D2 receptor |
| UniProt Protein Name: | Prostaglandin D2 receptor |
| UniProt Synonym Protein Names: | Prostanoid DP receptor |
| Protein Family: | Prostaglandin D2 receptor |
| UniProt Gene Name: | PTGDR |
 | Western blot analysis of extracts of NIH/3T3 cells, using PTGDR antibody (CAB12877) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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