Metabolism Antibodies 1

Anti-PTDSS1 Antibody (CAB13065)

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SKU:
CAB13065
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-PTDSS1 Antibody
Antibody SKU:CAB13065
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human PTDSS1 (NP_055569.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:Raji
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human PTDSS1 (NP_055569.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASC VGSR TLSK DDVN YKMH FRMI NEQQ VEDI TIDF FYRP HTIT LLSF TIVS LMYF AFTR DDSV PEDN IW
Gene ID:9791
Uniprot:P48651
Cellular Location:Endoplasmic reticulum membrane, Multi-pass membrane protein
Calculated MW:56kDa
Observed MW:55kDa
Synonyms:PTDSS1, LMHD, PSS1, PSSA
Background:The protein encoded by this gene catalyzes the formation of phosphatidylserine from either phosphatidylcholine or phosphatidylethanolamine. Phosphatidylserine localizes to the mitochondria-associated membrane of the endoplasmic reticulum, where it serves a structural role as well as a signaling role. Defects in this gene are a cause of Lenz-Majewski hyperostotic dwarfism. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:PTDSS1: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine. Belongs to the phosphatidyl serine synthase family.
UniProt Protein Details:

Protein type:EC 2.7.8.29; Membrane protein, integral; Mitochondrial; Lipid Metabolism - glycerophospholipid; Membrane protein, multi-pass; Transferase

Chromosomal Location of Human Ortholog: 8q22

Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane

Molecular Function:transferase activity

Biological Process: phosphatidylserine biosynthetic process; phospholipid biosynthetic process

Disease: Lenz-majewski Hyperostotic Dwarfism

NCBI Summary:The protein encoded by this gene catalyzes the formation of phosphatidylserine from either phosphatidylcholine or phosphatidylethanolamine. Phosphatidylserine localizes to the mitochondria-associated membrane of the endoplasmic reticulum, where it serves a structural role as well as a signaling role. Defects in this gene are a cause of Lenz-Majewski hyperostotic dwarfism. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
UniProt Code:P48651
NCBI GenInfo Identifier:1346881
NCBI Gene ID:9791
NCBI Accession:P48651.1
UniProt Secondary Accession:P48651,Q9BUQ5, B4DE85, E5RFC5,
UniProt Related Accession:P48651
Molecular Weight:34,579 Da
NCBI Full Name:Phosphatidylserine synthase 1
NCBI Synonym Full Names:phosphatidylserine synthase 1
NCBI Official Symbol:PTDSS1  
NCBI Official Synonym Symbols:LMHD; PSS1; PSSA  
NCBI Protein Information:phosphatidylserine synthase 1
UniProt Protein Name:Phosphatidylserine synthase 1
UniProt Synonym Protein Names:Serine-exchange enzyme I
Protein Family:Phosphatidylserine synthase
UniProt Gene Name:PTDSS1  
UniProt Entry Name:PTSS1_HUMAN
Anti-PTDSS1 Antibody (CAB13065)Western blot analysis of extracts of Raji cells, using PTDSS1 antibody (CAB13065) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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