Cell Biology Antibodies 11

Anti-PTCRA Antibody (CAB7150)

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SKU:
CAB7150
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PTCRA Antibody
Antibody SKU:CAB7150
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 172-281 of human PTCRA (NP_612153.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:K-562, Jurkat, HL-60, B cells, THP-1, Raji
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 172-281 of human PTCRA (NP_612153.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LCDP AGPL PSPA TTTR LRAL GSHR LHPA TETG GREA TSSP RPQP RDRR WGDT PPGR KPGS PVWG EGSY LSSY PTCP AQAW CSRS ALRA PSSS LGAF FAGD LPPP LQAG AA
Gene ID:171558
Uniprot:Q6ISU1
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:18kDa/26kDa/29kDa
Observed MW:37kDa
Synonyms:PTCRA, PT-ALPHA, PTA
Background:The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:PTCRA: The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: integral to membrane

Molecular Function:protein binding

NCBI Summary:The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
UniProt Code:Q6ISU1
NCBI GenInfo Identifier:74736631
NCBI Gene ID:171558
NCBI Accession:Q6ISU1.1
UniProt Secondary Accession:Q6ISU1,Q5TFZ7,
UniProt Related Accession:Q6ISU1
Molecular Weight:281
NCBI Full Name:Pre T-cell antigen receptor alpha
NCBI Synonym Full Names:pre T-cell antigen receptor alpha
NCBI Official Symbol:PTCRA  
NCBI Official Synonym Symbols:PTA; PT-ALPHA  
NCBI Protein Information:pre T-cell antigen receptor alpha; pT-alpha-TCR; pre-T-cell receptor alpha chain
UniProt Protein Name:Pre T-cell antigen receptor alpha
UniProt Synonym Protein Names:pT-alpha-TCR
Protein Family:Pre T-cell antigen receptor
UniProt Gene Name:PTCRA  
UniProt Entry Name:PTCRA_HUMAN
Anti-PTCRA Antibody (CAB7150)Western blot analysis of extracts of various cell lines, using PTCRA antibody (CAB7150) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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