Cell Biology Antibodies 11
Anti-PTCRA Antibody (CAB7150)
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- SKU:
- CAB7150
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PTCRA Antibody |
| Antibody SKU: | CAB7150 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 172-281 of human PTCRA (NP_612153.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | K-562, Jurkat, HL-60, B cells, THP-1, Raji |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 172-281 of human PTCRA (NP_612153.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LCDP AGPL PSPA TTTR LRAL GSHR LHPA TETG GREA TSSP RPQP RDRR WGDT PPGR KPGS PVWG EGSY LSSY PTCP AQAW CSRS ALRA PSSS LGAF FAGD LPPP LQAG AA |
| Gene ID: | 171558 |
| Uniprot: | Q6ISU1 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 18kDa/26kDa/29kDa |
| Observed MW: | 37kDa |
| Synonyms: | PTCRA, PT-ALPHA, PTA |
| Background: | The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | PTCRA: The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: integral to membrane Molecular Function:protein binding |
| NCBI Summary: | The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] |
| UniProt Code: | Q6ISU1 |
| NCBI GenInfo Identifier: | 74736631 |
| NCBI Gene ID: | 171558 |
| NCBI Accession: | Q6ISU1.1 |
| UniProt Secondary Accession: | Q6ISU1,Q5TFZ7, |
| UniProt Related Accession: | Q6ISU1 |
| Molecular Weight: | 281 |
| NCBI Full Name: | Pre T-cell antigen receptor alpha |
| NCBI Synonym Full Names: | pre T-cell antigen receptor alpha |
| NCBI Official Symbol: | PTCRA |
| NCBI Official Synonym Symbols: | PTA; PT-ALPHA |
| NCBI Protein Information: | pre T-cell antigen receptor alpha; pT-alpha-TCR; pre-T-cell receptor alpha chain |
| UniProt Protein Name: | Pre T-cell antigen receptor alpha |
| UniProt Synonym Protein Names: | pT-alpha-TCR |
| Protein Family: | Pre T-cell antigen receptor |
| UniProt Gene Name: | PTCRA |
| UniProt Entry Name: | PTCRA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PTCRA antibody (CAB7150) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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