Anti-PTBP2 Antibody (CAB9124)
- SKU:
- CAB9124
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PTBLP
- Synonyms:
- brPTB
- Synonyms:
- nPTB
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | PTBP2 Rabbit mAb |
| Product Code: | CAB9124 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | PTBLP, brPTB, nPTB |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PTBP2 |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, RD, SH-SY5Y, Mouse testis, Rat testis |
| Immunogen: | A synthesized peptide derived from human PTBP2 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 58155 |
| Uniprot: | Q9UKA9 |
| Cellular Location: | Nucleus |
| Calculated MW: | 57kDa |
| Observed MW: | 57kDa |
| UniProt Protein Function: | PTBP2: RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre- mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding; RNA processing Chromosomal Location of Human Ortholog: 1p21.3 Cellular Component: spliceosome Molecular Function:mRNA binding; nucleotide binding Biological Process: mRNA splice site selection; negative regulation of RNA splicing |
| NCBI Summary: | The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q9UKA9 |
| NCBI GenInfo Identifier: | 74761983 |
| NCBI Gene ID: | 58155 |
| NCBI Accession: | Q9UKA9.1 |
| UniProt Secondary Accession: | Q9UKA9,Q8N0Z1, Q8N160, Q8NFB0, Q8NFB1, Q969N9, Q96Q76 |
| UniProt Related Accession: | Q9UKA9 |
| Molecular Weight: | 531 |
| NCBI Full Name: | Polypyrimidine tract-binding protein 2 |
| NCBI Synonym Full Names: | polypyrimidine tract binding protein 2 |
| NCBI Official Symbol: | PTBP2 |
| NCBI Official Synonym Symbols: | nPTB; PTBLP; brPTB |
| NCBI Protein Information: | polypyrimidine tract-binding protein 2; PTB-like protein; neurally-enriched homolog of PTB; neural polypyrimidine tract binding protein |
| UniProt Protein Name: | Polypyrimidine tract-binding protein 2 |
| UniProt Synonym Protein Names: | Neural polypyrimidine tract-binding protein; Neurally-enriched homolog of PTB; PTB-like protein |
| Protein Family: | Polypyrimidine tract-binding protein |
| UniProt Gene Name: | PTBP2 |
| UniProt Entry Name: | PTBP2_HUMAN |
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