Epigenetics & Nuclear Signaling Antibodies 2
Anti-PTBP2 Antibody (CAB6054)
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- SKU:
- CAB6054
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-PTBP2 Antibody |
| Antibody SKU: | CAB6054 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human PTBP2 (NP_001287918.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:1000 - 1:4000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, HeLa, Mouse brain, Mouse testis, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human PTBP2 (NP_001287918.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDGI VTEV AVGV KRGS DELL SGSV LSSP NSNM SSMV VTAN GNDS KKFK GEDK MDGA PSRV LHIR KLPG EVTE TEVI ALGL PFGK VTNI LMLK GKNQ AFLE LATE EAAI TMVN YYSA VTPH LRNQ PIYI QYSN HKEL KTDN TLNQ RAQA VLQA VTAV QTAN TPLS GTTV SESA VTPA QSPV LRII IDNM YYPV TLDV LHQI FSKF GAVL KIIT FTKN NQFQ ALLQ YGDP VNAQ QAKL ALDG QNIY NACC TLRI DFSK LVNL NVKY NNDK SRDY TRPD LPSG |
| Gene ID: | 58155 |
| Uniprot: | Q9UKA9 |
| Cellular Location: | Nucleus |
| Calculated MW: | 37kDa/38kDa/57kDa/58kDa |
| Observed MW: | 57kDa |
| Synonyms: | PTBP2, PTBLP, brPTB, nPTB |
| Background: | The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | PTBP2: RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre- mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding; RNA processing Chromosomal Location of Human Ortholog: 1p21.3 Cellular Component: spliceosome Molecular Function:mRNA binding; nucleotide binding Biological Process: mRNA splice site selection; negative regulation of RNA splicing |
| NCBI Summary: | The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q9UKA9 |
| NCBI GenInfo Identifier: | 74761983 |
| NCBI Gene ID: | 58155 |
| NCBI Accession: | Q9UKA9.1 |
| UniProt Secondary Accession: | Q9UKA9,Q8N0Z1, Q8N160, Q8NFB0, Q8NFB1, Q969N9, Q96Q76 |
| UniProt Related Accession: | Q9UKA9 |
| Molecular Weight: | 531 |
| NCBI Full Name: | Polypyrimidine tract-binding protein 2 |
| NCBI Synonym Full Names: | polypyrimidine tract binding protein 2 |
| NCBI Official Symbol: | PTBP2 |
| NCBI Official Synonym Symbols: | nPTB; PTBLP; brPTB |
| NCBI Protein Information: | polypyrimidine tract-binding protein 2; PTB-like protein; neurally-enriched homolog of PTB; neural polypyrimidine tract binding protein |
| UniProt Protein Name: | Polypyrimidine tract-binding protein 2 |
| UniProt Synonym Protein Names: | Neural polypyrimidine tract-binding protein; Neurally-enriched homolog of PTB; PTB-like protein |
| Protein Family: | Polypyrimidine tract-binding protein |
| UniProt Gene Name: | PTBP2 |
| UniProt Entry Name: | PTBP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PTBP2 antibody (CAB6054) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded rat brain using PTBP2 Rabbit pAb (CAB6054) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human brain using PTBP2 Rabbit pAb (CAB6054) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse testis using PTBP2 Rabbit pAb (CAB6054) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using PTBP2 Rabbit pAb (CAB6054) at dilution of 1:100 (40x lens). |
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