| UniProt Protein Function: | PSMD6: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Belongs to the proteasome subunit S10 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 3p14.1 Cellular Component: nucleoplasm; proteasome complex; proteasome regulatory particle; cytosol Molecular Function:ATPase activity Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; proteolysis; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle |
| NCBI Summary: | This gene encodes a member of the protease subunit S10 family. The encoded protein is a subunit of the 26S proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012] |
| UniProt Code: | Q15008 |
| NCBI GenInfo Identifier: | 7661914 |
| NCBI Gene ID: | 9861 |
| NCBI Accession: | NP_055629.1 |
| UniProt Secondary Accession: | Q15008,Q6UV22, A8K2E0, E9PHI9, |
| UniProt Related Accession: | Q15008 |
| Molecular Weight: | 51,923 Da |
| NCBI Full Name: | 26S proteasome non-ATPase regulatory subunit 6 isoform 2 |
| NCBI Synonym Full Names: | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 |
| NCBI Official Symbol: | PSMD6 |
| NCBI Official Synonym Symbols: | S10; Rpn7; p42A; p44S10; SGA-113M |
| NCBI Protein Information: | 26S proteasome non-ATPase regulatory subunit 6; breast cancer-associated protein SGA-113M; phosphonoformate immuno-associated protein 4; proteasome regulatory particle subunit p44S10 |
| UniProt Protein Name: | 26S proteasome non-ATPase regulatory subunit 6 |
| UniProt Synonym Protein Names: | 26S proteasome regulatory subunit RPN7; 26S proteasome regulatory subunit S10; Breast cancer-associated protein SGA-113M; Phosphonoformate immuno-associated protein 4; Proteasome regulatory particle subunit p44S10; p42A |
| UniProt Gene Name: | PSMD6 |
| UniProt Entry Name: | PSMD6_HUMAN |
