Cell Biology Antibodies 10
Anti-PSMD12 Antibody (CAB6708)
- SKU:
- CAB6708
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-PSMD12 Antibody |
Antibody SKU: | CAB6708 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 197-456 of human PSMD12 (NP_002807.1). |
Application: | WB IHC |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | MCF7, BT-474, HT-29, Mouse heart, Rat heart, Rat lung |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 197-456 of human PSMD12 (NP_002807.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | KDYI RTQI ISKK INTK FFQE ENTE KLKL KYYN LMIQ LDQH EGSY LSIC KHYR AIYD TPCI QAES EKWQ QALK SVVL YVIL APFD NEQS DLVH RISG DKKL EEIP KYKD LLKL FTTM ELMR WSTL VEDY GMEL RKGS LESP ATDV FGST EEGE KRWK DLKN RVVE HNIR IMAK YYTR ITMK RMAQ LLDL SVDE SEAF LSNL VVNK TIFA KVDR LAGI INFQ RPKD PNNL LNDW SQKL NSLM SLVN KTTH LIAK EEMI HNLQ |
Gene ID: | 5718 |
Uniprot: | O00232 |
Cellular Location: | |
Calculated MW: | 50kDa/52kDa |
Observed MW: | 53kDa |
Synonyms: | PSMD12, Rpn5, p55, STISS |
Background: | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | PSMD12: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Belongs to the proteasome subunit p55 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protease; Proteasome complex Chromosomal Location of Human Ortholog: 17q24.2 Cellular Component: proteasome complex; nucleoplasm; membrane; proteasome regulatory particle; cytosol Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis |
NCBI Summary: | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. [provided by RefSeq, Jul 2008] |
UniProt Code: | O00232 |
NCBI GenInfo Identifier: | 20978544 |
NCBI Gene ID: | 5718 |
NCBI Accession: | O00232.3 |
UniProt Secondary Accession: | O00232,Q53HA2, Q6P053, A6NP15, |
UniProt Related Accession: | O00232 |
Molecular Weight: | 50,579 Da |
NCBI Full Name: | 26S proteasome non-ATPase regulatory subunit 12 |
NCBI Synonym Full Names: | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 |
NCBI Official Symbol: | PSMD12 |
NCBI Official Synonym Symbols: | p55; Rpn5 |
NCBI Protein Information: | 26S proteasome non-ATPase regulatory subunit 12; 26S proteasome regulatory subunit p55; 26S proteasome regulatory subunit RPN5 |
UniProt Protein Name: | 26S proteasome non-ATPase regulatory subunit 12 |
UniProt Synonym Protein Names: | 26S proteasome regulatory subunit RPN5; 26S proteasome regulatory subunit p55 |
Protein Family: | 26S proteasome non-ATPase regulatory |
UniProt Gene Name: | PSMD12 |
UniProt Entry Name: | PSD12_HUMAN |