| Synonyms: | PSMC5, S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG, ATPase 5 |
| Background: | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | RPT6: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. Belongs to the AAA ATPase family. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Proteasome complex; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 17q23.3 Cellular Component: nucleoplasm; proteasome complex; membrane; proteasome regulatory particle; cytoplasm; inclusion body; cytoplasmic vesicle; nucleus; cytosol Molecular Function:thyrotropin-releasing hormone receptor binding; protein binding; TATA-binding protein binding; ATPase activity; transcription cofactor activity; transcription factor binding; ATP binding Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; positive regulation of transcription, DNA-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of programmed cell death; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of transcription, DNA-dependent; G1/S transition of mitotic cell cycle; negative regulation of apoptosis |
| NCBI Summary: | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] |
| UniProt Code: | P62195 |
| NCBI GenInfo Identifier: | 49065819 |
| NCBI Gene ID: | 5705 |
| NCBI Accession: | P62195.1 |
| UniProt Secondary Accession: | P62195,O35051, O43208, P47210, P52915, P52916, A8K3Z3 A8K763, |
| UniProt Related Accession: | P62195 |
| Molecular Weight: | 406 |
| NCBI Full Name: | 26S protease regulatory subunit 8 |
| NCBI Synonym Full Names: | proteasome (prosome, macropain) 26S subunit, ATPase, 5 |
| NCBI Official Symbol: | PSMC5 |
| NCBI Official Synonym Symbols: | S8; p45; SUG1; SUG-1; TBP10; TRIP1; p45/SUG |
| NCBI Protein Information: | 26S protease regulatory subunit 8; MSUG1 protein; proteasome subunit p45; thyroid receptor interactor 1; Tat-binding protein homolog 10; proteasome 26S ATPase subunit 5; proteasome 26S subunit ATPase 5; 26S proteasome AAA-ATPase subunit RPT6; thyroid horm |
| UniProt Protein Name: | 26S protease regulatory subunit 8 |
| UniProt Synonym Protein Names: | 26S proteasome AAA-ATPase subunit RPT6; Proteasome 26S subunit ATPase 5; Proteasome subunit p45; Thyroid hormone receptor-interacting protein 1; TRIP1; p45/SUG |
| Protein Family: | 26S protease regulatory |
| UniProt Gene Name: | PSMC5 |
| UniProt Entry Name: | PRS8_HUMAN |
