Cell Biology Antibodies 9
Anti-PSCA Antibody (CAB5614)
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- SKU:
- CAB5614
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PSCA Antibody |
| Antibody SKU: | CAB5614 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 12-114 of human PSCA (NP_005663.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse kidney, Mouse heart, Mouse testis, Mouse eye |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 12-114 of human PSCA (NP_005663.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LLCY SCKA QVSN EDCL QVEN CTQL GEQC WTAR IRAV GLLT VISK GCSL NCVD DSQD YYVG KKNI TCCD TDLC NASG AHAL QPAA AILA LLPA LGLL LWGP GQL |
| Gene ID: | 8000 |
| Uniprot: | O43653 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor |
| Calculated MW: | 12kDa |
| Observed MW: | 36kDa |
| Synonyms: | PSCA, PRO232 |
| Background: | This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | PSCA: May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 8q24.2 Cellular Component: plasma membrane |
| UniProt Code: | O43653 |
| NCBI GenInfo Identifier: | 10720240 |
| NCBI Gene ID: | |
| NCBI Accession: | O43653.1 |
| UniProt Secondary Accession: | O43653,Q6UW92, |
| Molecular Weight: | |
| NCBI Full Name: | Prostate stem cell antigen |
| UniProt Protein Name: | Prostate stem cell antigen |
| Protein Family: | Prostate stem cell antigen |
| UniProt Gene Name: | PSCA |
| UniProt Entry Name: | PSCA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PSCA antibody (CAB5614) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). |
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