Anti-PSA/KLK3 Antibody (CAB4355)
- SKU:
- CAB4355
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- APS
- Synonyms:
- KLK2A1
- Synonyms:
- PSA
- Synonyms:
- hK3
- Research Area:
- Cell Biology
Description
| Product Name: | PSA/KLK3 Rabbit mAb |
| Product Code: | CAB4355 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | APS, KLK2A1, PSA, hK3 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PSA/KLK3 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | LNCaP |
| Immunogen: | A synthesized peptide derived from human PSA/KLK3 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 354 |
| Uniprot: | P07288 |
| Calculated MW: | 34kDa |
| Observed MW: | 30KDa |
| UniProt Protein Function: | PSA: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Forms heterodimer with SERPINA5. Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Belongs to the peptidase S1 family. Kallikrein subfamily. |
| UniProt Protein Details: | Protein type:Protease; Secreted, signal peptide; EC 3.4.21.77; Secreted Chromosomal Location of Human Ortholog: 19q13.41 Cellular Component: extracellular region; nucleus Molecular Function:protein binding; serine-type peptidase activity; serine-type endopeptidase activity Biological Process: negative regulation of angiogenesis; cellular protein metabolic process; proteolysis |
| NCBI Summary: | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P07288 |
| NCBI GenInfo Identifier: | 130989 |
| NCBI Gene ID: | 354 |
| NCBI Accession: | P07288.2 |
| UniProt Secondary Accession: | P07288,Q15096, Q16272, Q86TG8, Q8IXI4, C9JXH3, G3V0H4 G3XAE3, |
| UniProt Related Accession: | P07288 |
| Molecular Weight: | 28,741 Da |
| NCBI Full Name: | Prostate-specific antigen |
| NCBI Synonym Full Names: | kallikrein-related peptidase 3 |
| NCBI Official Symbol: | KLK3 |
| NCBI Official Synonym Symbols: | APS; PSA; hK3; KLK2A1 |
| NCBI Protein Information: | prostate-specific antigen; seminin; P-30 antigen; kallikrein-3; semenogelase; gamma-seminoprotein; prostate specific antigen |
| UniProt Protein Name: | Prostate-specific antigen |
| UniProt Synonym Protein Names: | Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase |
| Protein Family: | Prostate-specific antigen |
| UniProt Gene Name: | KLK3 |
| UniProt Entry Name: | KLK3_HUMAN |
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