Cell Biology Antibodies 6

Anti-PRSS21 Antibody (CAB16100)

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SKU:
CAB16100
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PRSS21 Antibody
Antibody SKU:CAB16100
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 150-220 of human PRSS21 (NP_006790.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse testis, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 150-220 of human PRSS21 (NP_006790.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TKHI QPIC LQAS TFEF ENRT DCWV TGWG YIKE DEAL PSPH TLQE VQVA IINN SMCN HLFL KYSF RKDI FGD
Gene ID:10942
Uniprot:Q9Y6M0
Cellular Location:Cell membrane, GPI-anchor, Lipid-anchor
Calculated MW:33kDa/34kDa
Observed MW:36kDa
Synonyms:PRSS21, ESP-1, ESP1, TEST1, TESTISIN, testisin
Background:This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniProt Protein Function:PRSS21: Could regulate proteolytic events associated with testicular germ cell maturation. Belongs to the peptidase S1 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protease; EC 3.4.21.-; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: cytoplasm; membrane

Molecular Function:protein binding; serine-type peptidase activity

NCBI Summary:This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
UniProt Code:Q9Y6M0
NCBI GenInfo Identifier:13633973
NCBI Gene ID:10942
NCBI Accession:Q9Y6M0.1
UniProt Secondary Accession:Q9Y6M0,Q9NS34, Q9P2V6,
UniProt Related Accession:Q9Y6M0
Molecular Weight:33,562 Da
NCBI Full Name:Testisin
NCBI Synonym Full Names:protease, serine 21
NCBI Official Symbol:PRSS21  
NCBI Official Synonym Symbols:ESP1; ESP-1; TEST1; TESTISIN  
NCBI Protein Information:testisin
UniProt Protein Name:Testisin
UniProt Synonym Protein Names:Eosinophil serine protease 1; ESP-1; Serine protease 21
Protein Family:Testisin
UniProt Gene Name:PRSS21  
UniProt Entry Name:TEST_HUMAN
Anti-PRSS21 Antibody (CAB16100)Western blot analysis of extracts of various cell lines, using PRSS21 antibody (CAB16100) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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