Cell Biology Antibodies 4
Anti-PRRG2 Antibody (CAB14380)
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- SKU:
- CAB14380
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PRRG2 Antibody |
| Antibody SKU: | CAB14380 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human PRRG2 (NP_001303264.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse lung, Rat liver, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human PRRG2 (NP_001303264.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSLG PEVF LGPP EAQS FLSS HTRI PRAN HWDL ELLT PGNL EREC LEER CSWE EARE YFED NTLT ERFW ESYI YNGK GGRG RVDV ASLA VGLT GGIL LIVL AGLG AFWY LRWR QHRG QQPC PQEA GLIS PLSP LNPL GPPT PLPP PPPP PPGL PTYE QALA ASGV HDAP PPPY TSLR RPH |
| Gene ID: | 5639 |
| Uniprot: | O14669 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 22kDa |
| Observed MW: | 23kDa |
| Synonyms: | PRRG2, PRGP2 |
| Background: | The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | Subunit structure: Interacts with NEDD4 |
| UniProt Protein Details: | By similarity. Subcellular location: Membrane; Single-pass type I membrane protein. Tissue specificity: Highly expressed in the thyroid. Post-translational modification: Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase. Sequence similarities: Contains 1 Gla (gamma-carboxy-glutamate) domain. |
| NCBI Summary: | The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] |
| UniProt Code: | O14669 |
| NCBI GenInfo Identifier: | 4506137 |
| NCBI Gene ID: | 5639 |
| NCBI Accession: | NP_000942 |
| UniProt Related Accession: | O14669 |
| Molecular Weight: | 22 |
| NCBI Full Name: | transmembrane gamma-carboxyglutamic acid protein 2 isoform 1 |
| NCBI Synonym Full Names: | proline rich and Gla domain 2 |
| NCBI Official Symbol: | PRRG2 |
| NCBI Official Synonym Symbols: | PRGP2 |
| NCBI Protein Information: | transmembrane gamma-carboxyglutamic acid protein 2 |
| UniProt Protein Name: | Transmembrane gamma-carboxyglutamic acid protein 2 |
| UniProt Synonym Protein Names: | Proline-rich gamma-carboxyglutamic acid protein 2 |
| Protein Family: | Transmembrane gamma-carboxyglutamic acid protein |
| UniProt Gene Name: | PRRG2 |
| UniProt Entry Name: | TMG2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PRRG2 antibody (CAB14380) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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