Cardiovascular Antibodies
Anti-PROZ Antibody (CAB16082)
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- SKU:
- CAB16082
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-PROZ Antibody |
| Antibody SKU: | CAB16082 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-340 of human PROZ (NP_003882.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, 293T, Mouse kidney, Rat liver, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-340 of human PROZ (NP_003882.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SLLH RNIT VKTY FNRT SQDP LMIK ITHV HVHM RYDA DAGE NDLS LLEL EWPI QCPG AGLP VCTP EKDF AEHL LIPR TRGL LSGW ARNG TDLG NSLT TRPV TLVE GEEC GQVL NVTV TTRT Y |
| Gene ID: | 8858 |
| Uniprot: | P22891 |
| Cellular Location: | Secreted |
| Calculated MW: | 44kDa/47kDa |
| Observed MW: | 48kDa |
| Synonyms: | PROZ, PZ |
| Background: | This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. |
| NCBI Summary: | This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P22891 |
| NCBI GenInfo Identifier: | 50960132 |
| NCBI Gene ID: | 8858 |
| NCBI Accession: | |
| UniProt Related Accession: | P22891 |
| Molecular Weight: | |
| NCBI Full Name: | Protein Z, vitamin K-dependent plasma glycoprotein |
| NCBI Synonym Full Names: | protein Z, vitamin K dependent plasma glycoprotein |
| NCBI Official Symbol: | PROZ |
| NCBI Official Synonym Symbols: | PZ |
| NCBI Protein Information: | vitamin K-dependent protein Z |
| UniProt Protein Name: | |
| UniProt Gene Name: |
 | Western blot analysis of extracts of various cell lines, using PROZ antibody (CAB16082) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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