Cell Death Antibodies 2
Anti-Protein S100-A9 Antibody (CAB9842)
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- SKU:
- CAB9842
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-Protein S100-A9 Antibody |
| Antibody SKU: | CAB9842 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human S100A9 (NP_002956.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse spleen, Rat spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human S100A9 (NP_002956.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTCK MSQL ERNI ETII NTFH QYSV KLGH PDTL NQGE FKEL VRKD LQNF LKKE NKNE KVIE HIME DLDT NADK QLSF EEFI MLMA RLTW ASHE KMHE GDEG PGHH HKPG LGEG TP |
| Gene ID: | 6280 |
| Uniprot: | P06702 |
| Cellular Location: | Cell membrane, Cytoplasm, Peripheral membrane protein, Secreted, cytoskeleton |
| Calculated MW: | 13kDa |
| Observed MW: | 13kDa |
| Synonyms: | S100A9, 60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14 |
| Background: | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits antifungal and antibacterial activity. |
| UniProt Protein Function: | S100A9: a calcium-binding regulatory protein of the S-100 family expressed by macrophages in acutely inflammated tissues and in chronic inflammations. May be an inhibitor of protein kinases. Also expressed in epithelial cells constitutively or induced during dermatoses. May interact with components of the intermediate filaments in monocytes and epithelial cells. Interacts with CEACAM3 in a calcium-dependent manner. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 1q21 Cellular Component: cytoskeleton; cytosol; extracellular region; extracellular space; nucleus; plasma membrane Molecular Function:arachidonic acid binding; calcium ion binding; microtubule binding; protein binding; RAGE receptor binding; signal transducer activity; zinc ion binding Biological Process: activation of NF-kappaB transcription factor; autophagy; caspase activation; cell-cell signaling; chemokine production; cytokine production; defense response to bacterium; defense response to fungus; inflammatory response; leukocyte migration during inflammatory response; neutrophil chemotaxis; positive regulation of cell growth; positive regulation of inflammatory response; regulation of cytoskeleton organization and biogenesis; sequestering of zinc ion |
| NCBI Summary: | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits antifungal and antibacterial activity. [provided by RefSeq, Nov 2014] |
| UniProt Code: | P06702 |
| NCBI GenInfo Identifier: | 115444 |
| NCBI Gene ID: | 6280 |
| NCBI Accession: | P06702.1 |
| UniProt Secondary Accession: | P06702,Q6FGA1, Q9NYM0, Q9UCJ1, D3DV36, |
| UniProt Related Accession: | P06702 |
| Molecular Weight: | 13,242 Da |
| NCBI Full Name: | Protein S100-A9 |
| NCBI Synonym Full Names: | S100 calcium binding protein A9 |
| NCBI Official Symbol: | S100A9 |
| NCBI Official Synonym Symbols: | MIF; NIF; P14; CAGB; CFAG; CGLB; L1AG; LIAG; MRP14; 60B8AG; MAC387 |
| NCBI Protein Information: | protein S100-A9 |
| UniProt Protein Name: | Protein S100-A9 |
| UniProt Synonym Protein Names: | Calgranulin-B; Calprotectin L1H subunit; Leukocyte L1 complex heavy chain; Migration inhibitory factor-related protein 14; MRP-14; p14; S100 calcium-binding protein A9 |
| Protein Family: | Protein |
| UniProt Gene Name: | S100A9 |
| UniProt Entry Name: | S10A9_HUMAN |
 | Western blot analysis of extracts of Mouse spleen, using S100A9 antibody (CAB9842) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Western blot analysis of extracts of Rat spleen, using S100A9 antibody (CAB9842) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded rat spleen using S100A9 antibody (CAB9842) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human tonsil using S100A9 antibody (CAB9842) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spleen using S100A9 antibody (CAB9842) at dilution of 1:100 (40x lens). |
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