Cell Biology Antibodies 14
Anti-PROP1 Antibody (CAB16962)
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- SKU:
- CAB16962
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PROP1 Antibody |
| Antibody SKU: | CAB16962 |
| Antibody Size: | 20uL, 50 uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PROP1 (NP_006252.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PROP1 (NP_006252.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GGGR SRFS PQGG QRGR PHSR RRHR TTFS PVQL EQLE SAFG RNQY PDIW ARES LARD TGLS EARI QVWF QNRR AKQR KQER SLLQ PLAH LSPA AFSS FLPE S |
| Gene ID: | 5626 |
| Uniprot: | O75360 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | PROP1, CPHD2, PROP-1 |
| Background: | This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone. |
| UniProt Protein Function: | PROP1: Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes. Defects in PROP1 are the cause of pituitary hormone deficiency combined type 2 (CPHD2); also known as pituitary dwarfism III. It is characterized by impaired production of growth hormone (GH) and one or more of the other five anterior pituitary hormones. Belongs to the paired homeobox family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 5q35.3 Cellular Component: transcription factor complex; nucleus Molecular Function:protein C-terminus binding; protein binding; sequence-specific DNA binding; beta-catenin binding; chromatin binding Biological Process: blood vessel development; cell migration; central nervous system development; dorsal/ventral pattern formation; hypophysis morphogenesis; positive regulation of transcription from RNA polymerase II promoter; hypothalamus cell differentiation; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; somatotropin secreting cell differentiation; negative regulation of apoptosis Disease: Pituitary Hormone Deficiency, Combined, 2 |
| NCBI Summary: | This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone. [provided by RefSeq, Sep 2011] |
| UniProt Code: | O75360 |
| NCBI GenInfo Identifier: | 262359909 |
| NCBI Gene ID: | 5626 |
| NCBI Accession: | NP_006252.3 |
| UniProt Related Accession: | O75360 |
| Molecular Weight: | 24,984 Da |
| NCBI Full Name: | homeobox protein prophet of Pit-1 |
| NCBI Synonym Full Names: | PROP paired-like homeobox 1 |
| NCBI Official Symbol: | PROP1 |
| NCBI Official Synonym Symbols: | CPHD2; PROP-1 |
| NCBI Protein Information: | homeobox protein prophet of Pit-1; pituitary-specific homeodomain factor; prophet of Pit1, paired-like homeodomain transcription factor |
| UniProt Protein Name: | Homeobox protein prophet of Pit-1 |
| UniProt Synonym Protein Names: | Pituitary-specific homeodomain factor |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | PROP1 |
| UniProt Entry Name: | PROP1_HUMAN |
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