Anti-Prolactin Receptor Antibody (CAB4121)
- SKU:
- CAB4121
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HPRL
- Synonyms:
- MFAB
- Synonyms:
- hPRLrI
- Research Area:
- Cell Biology
Description
| Product Name: | Prolactin Receptor Rabbit mAb |
| Product Code: | CAB4121 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | HPRL, MFAB, hPRLrI |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Prolactin Receptor |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, BT-474, MCF7 |
| Immunogen: | A synthesized peptide derived from human Prolactin Receptor |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5618 |
| Uniprot: | P16471 |
| Calculated MW: | 95kDa |
| Observed MW: | 90KDa |
| UniProt Protein Function: | PRLR: receptor for the anterior pituitary hormone prolactin and placental lactogen I and II. Interacts with Cyclophilin A, differentially regulating various signaling pathways from the PrlR. Prolactin signaling is attenuated by threonine and tyrosine phosphorylation. Two alternative splice isoforms have been identified. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: 5p13.2 Cellular Component: cell surface; plasma membrane Molecular Function:peptide hormone binding; protein binding Biological Process: embryo implantation; transmembrane receptor protein tyrosine kinase activation (dimerization) Disease: Hyperprolactinemia; Multiple Fibroadenomas Of The Breast |
| NCBI Summary: | This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011] |
| UniProt Code: | P16471 |
| NCBI GenInfo Identifier: | 130321 |
| NCBI Gene ID: | 5618 |
| NCBI Accession: | P16471.1 |
| UniProt Secondary Accession: | P16471,Q16354, Q8TD75, Q8TD78, Q96P35, Q96P36, Q9BX87 Q9UHJ5, B2R882, D1MDP1, |
| UniProt Related Accession: | P16471 |
| Molecular Weight: | 70kDa |
| NCBI Full Name: | Prolactin receptor |
| NCBI Synonym Full Names: | prolactin receptor |
| NCBI Official Symbol: | PRLR |
| NCBI Official Synonym Symbols: | HPRL; MFAB; hPRLrI |
| NCBI Protein Information: | prolactin receptor |
| UniProt Protein Name: | Prolactin receptor |
| Protein Family: | Prolactin receptor |
| UniProt Gene Name: | PRLR |
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