Cell Biology Antibodies 17

Anti-Profilin1 Antibody (CAB9188)

(No reviews yet) Write a Review
SKU:
CAB9188
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-Profilin1 Antibody
Antibody SKU:CAB9188
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Profilin1
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, A-549, NIH/3T3, C6, U-251MG, Mouse brain, Mouse thymus, Rat kidney
Immunogen:A synthesized peptide derived from human Profilin1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5216
Uniprot:P07737
Cellular Location:
Calculated MW:15kDa
Observed MW:15KDa
Synonyms:ALS18
Background:This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]
UniProt Protein Function:profilin 1: a ubiquitous actin monomer-binding protein belonging to the profilin family. At high concentrations, profilin 1 prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Deletion of this gene is associated with Miller-Dieker syndrome.
UniProt Protein Details:

Protein type:Cytoskeletal; Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: cell cortex; cytoplasm; cytosol; focal adhesion; membrane; nucleus

Molecular Function:actin binding; actin monomer binding; adenyl-nucleotide exchange factor activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding

Biological Process: negative regulation of actin filament bundle formation; negative regulation of actin filament polymerization; negative regulation of stress fiber formation; positive regulation of actin filament bundle formation; positive regulation of actin filament polymerization; positive regulation of ATPase activity; protein stabilization; Wnt receptor signaling pathway, planar cell polarity pathway

Disease: Amyotrophic Lateral Sclerosis 18

NCBI Summary:This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]
UniProt Code:P07737
NCBI GenInfo Identifier:130979
NCBI Gene ID:5216
NCBI Accession:P07737.2
UniProt Secondary Accession:P07737,Q53Y44,
UniProt Related Accession:P07737
Molecular Weight:15,054 Da
NCBI Full Name:Profilin-1
NCBI Synonym Full Names:profilin 1
NCBI Official Symbol:PFN1  
NCBI Official Synonym Symbols:ALS18  
NCBI Protein Information:profilin-1
UniProt Protein Name:Profilin-1
UniProt Synonym Protein Names:Epididymis tissue protein Li 184a; Profilin I
UniProt Gene Name:PFN1  
UniProt Entry Name:PROF1_HUMAN
Anti-Profilin1 Antibody (CAB9188)Western blot - Profilin1 Rabbit mAb (CAB9188)
View AllClose

0 Reviews

View AllClose

Related Products