Cardiovascular Antibodies
Anti-PROCR Antibody (CAB13641)
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- SKU:
- CAB13641
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-PROCR Antibody |
| Antibody SKU: | CAB13641 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-209 of human PROCR (NP_006395.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NCI-H460, HT-29, SKOV3, A549, THP-1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-209 of human PROCR (NP_006395.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QDAS DGLQ RLHM LQIS YFRD PYHV WYQG NASL GGHL THVL EGPD TNTT IIQL QPLQ EPES WART QSGL QSYL LQFH GLVR LVHQ ERTL AFPL TIRC FLGC ELPP EGSR AHVF FEVA VNGS SFVS FRPE RALW QADT QVTS GVVT FTLQ QLNA YNRT RYEL REFL EDTC VQYV QKHI SAEN TKGS QTSR SYT |
| Gene ID: | 10544 |
| Uniprot: | Q9UNN8 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 26kDa |
| Observed MW: | 50kDa |
| Synonyms: | PROCR, CCCA, CCD41, EPCR, h-PROCR |
| Background: | The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. |
| UniProt Protein Function: | Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. |
| NCBI Summary: | The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q9UNN8 |
| NCBI GenInfo Identifier: | 13626550 |
| NCBI Gene ID: | 10544 |
| NCBI Accession: | Q9UNN8.1 |
| UniProt Secondary Accession: | Q9UNN8,Q14218, Q6IB56, Q96CB3, Q9ULX1, B2RC04, |
| UniProt Related Accession: | Q9UNN8 |
| Molecular Weight: | 26,671 Da |
| NCBI Full Name: | Endothelial protein C receptor |
| NCBI Synonym Full Names: | protein C receptor |
| NCBI Official Symbol: | PROCR |
| NCBI Official Synonym Symbols: | CCCA; EPCR; CCD41 |
| NCBI Protein Information: | endothelial protein C receptor |
| UniProt Protein Name: | Endothelial protein C receptor |
| UniProt Synonym Protein Names: | Activated protein C receptor; APC receptor; Endothelial cell protein C receptor; CD_antigen: CD201 |
| Protein Family: | Endothelial protein C receptor |
| UniProt Gene Name: | PROCR |
 | Western blot analysis of extracts of various cell lines, using PROCR antibody (CAB13641) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat liver using PROCR antibody (CAB13641) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat kidney using PROCR antibody (CAB13641) at dilution of 1:200 (40x lens). |
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