Cell Biology Antibodies 17
Anti-PRMT1 Antibody (CAB4502)
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- SKU:
- CAB4502
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ANM1
- Synonyms:
- HCP1
- Synonyms:
- HRMT1L2
- Synonyms:
- IR1B4
- Research Area:
- Cell Biology
Description
| Product Name: | PRMT1 Rabbit mAb |
| Product Code: | CAB4502 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ANM1, HCP1, HRMT1L2, IR1B4 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PRMT1 |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW620, Mouse brain |
| Immunogen: | A synthesized peptide derived from human PRMT1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3276 |
| Uniprot: | Q99873 |
| Calculated MW: | 42kDa |
| Observed MW: | 45KDa |
| UniProt Protein Function: | PRMT1: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Homodimer and heterodimer with PRMT8. The dimer can then associate to form a homohexamer. Interacts with ILF3, BTG1, BTG2, SUPT5H and interferon-alpha/beta receptor 1. Interacts with NFATC2IP. Widely expressed. By BTG1, BTG2 and ILF3. Belongs to the protein arginine N-methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Methyltransferase; EC 2.1.1.125; Nuclear receptor co-regulator; Methyltransferase, protein arginine Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol Molecular Function:identical protein binding; protein-arginine omega-N asymmetric methyltransferase activity; histone methyltransferase activity; methyltransferase activity; protein binding; N-methyltransferase activity Biological Process: histone methylation; peptidyl-arginine methylation; establishment and/or maintenance of chromatin architecture; cell surface receptor linked signal transduction; protein amino acid methylation; regulation of transcription, DNA-dependent; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; negative regulation of megakaryocyte differentiation; neurite development |
| NCBI Summary: | This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q99873 |
| NCBI GenInfo Identifier: | 161789011 |
| NCBI Gene ID: | 3276 |
| NCBI Accession: | Q99873.2 |
| UniProt Secondary Accession: | Q99873,Q15529, Q2VP93, Q6LEU5, Q8WUW5, Q99872, Q99874 Q9NZ04, Q9NZ05, Q9NZ06, B4E3C3, G5E9B6, |
| UniProt Related Accession: | Q99873 |
| Molecular Weight: | 361 |
| NCBI Full Name: | Protein arginine N-methyltransferase 1 |
| NCBI Synonym Full Names: | protein arginine methyltransferase 1 |
| NCBI Official Symbol: | PRMT1 |
| NCBI Official Synonym Symbols: | ANM1; HCP1; IR1B4; HRMT1L2 |
| NCBI Protein Information: | protein arginine N-methyltransferase 1; interferon receptor 1-bound protein 4; histone-arginine N-methyltransferase PRMT1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2 |
| UniProt Protein Name: | Protein arginine N-methyltransferase 1 |
| UniProt Synonym Protein Names: | Histone-arginine N-methyltransferase PRMT1 (EC:2.1.1.125); Interferon receptor 1-bound protein 4 |
| Protein Family: | Protein arginine N-methyltransferase |
| UniProt Gene Name: | PRMT1 |
| UniProt Entry Name: | ANM1_HUMAN |
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