Cell Biology Antibodies 2

Anti-PRLR Antibody (CAB10513)

(No reviews yet) Write a Review
SKU:
CAB10513
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-PRLR Antibody
Antibody SKU:CAB10513
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-234 of human PRLR (NP_000940.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, MCF7, Mouse ovary
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-234 of human PRLR (NP_000940.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QLPP GKPE IFKC RSPN KETF TCWW RPGT DGGL PTNY SLTY HREG ETLM HECP DYIT GGPN SCHF GKQY TSMW RTYI MMVN ATNQ MGSS FSDE LYVD VTYI VQPD PPLE LAVE VKQP EDRK PYLW IKWS PPTL IDLK TGWF TLLY EIRL KPEK AAEW EIHF AGQQ TEFK ILSL HPGQ KYLV QVRC KPDH GYWS AWSP ATFI QIPS DFTM ND
Gene ID:5618
Uniprot:P16471
Cellular Location:Membrane, Secreted, Single-pass type I membrane protein
Calculated MW:24-42kDa/57kDa/69kDa
Observed MW:70kDa
Synonyms:PRLR, HPRL, MFAB, hPRLrI
Background:This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer.
UniProt Protein Function:PRLR: receptor for the anterior pituitary hormone prolactin and placental lactogen I and II. Interacts with Cyclophilin A, differentially regulating various signaling pathways from the PrlR. Prolactin signaling is attenuated by threonine and tyrosine phosphorylation. Two alternative splice isoforms have been identified.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 5p13.2

Cellular Component: cell surface; plasma membrane

Molecular Function:peptide hormone binding; protein binding

Biological Process: embryo implantation; transmembrane receptor protein tyrosine kinase activation (dimerization)

Disease: Hyperprolactinemia; Multiple Fibroadenomas Of The Breast

NCBI Summary:This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
UniProt Code:P16471
NCBI GenInfo Identifier:130321
NCBI Gene ID:5618
NCBI Accession:P16471.1
UniProt Secondary Accession:P16471,Q16354, Q8TD75, Q8TD78, Q96P35, Q96P36, Q9BX87 Q9UHJ5, B2R882, D1MDP1,
UniProt Related Accession:P16471
Molecular Weight:70kDa
NCBI Full Name:Prolactin receptor
NCBI Synonym Full Names:prolactin receptor
NCBI Official Symbol:PRLR  
NCBI Official Synonym Symbols:HPRL; MFAB; hPRLrI  
NCBI Protein Information:prolactin receptor
UniProt Protein Name:Prolactin receptor
Protein Family:Prolactin receptor
UniProt Gene Name:PRLR  
Anti-PRLR Antibody (CAB10513)Western blot analysis of extracts of various cell lines, using PRLR antibody (CAB10513) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
View AllClose

0 Reviews

View AllClose

Related Products