Cell Biology Antibodies 6
Anti-PRL Antibody (CAB1618)
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- SKU:
- CAB1618
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PRL Antibody |
| Antibody SKU: | CAB1618 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-227 of human PRL (NP_001157030.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-937, PC-3, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-227 of human PRL (NP_001157030.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LPIC PGGA ARCQ VTLR DLFD RAVV LSHY IHNL SSEM FSEF DKRY THGR GFIT KAIN SCHT SSLA TPED KEQA QQMN QKDF LSLI VSIL RSWN EPLY HLVT EVRG MQEA PEAI LSKA VEIE EQTK RLLE GMEL IVSQ VHPE TKEN EIYP VWSG LPSL QMAD EESR LSAY YNLL HCLR RDSH KIDN YLKL LKCR IIHN NNC |
| Gene ID: | 5617 |
| Uniprot: | P01236 |
| Cellular Location: | Secreted |
| Calculated MW: | 25kDa |
| Observed MW: | 30kDa |
| Synonyms: | PRL, GHA1, prolactin |
| Background: | This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. |
| UniProt Protein Function: | prolactin: Prolactin acts primarily on the mammary gland by promoting lactation. Belongs to the somatotropin/prolactin family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Cytokine; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 6p22.3 Cellular Component: extracellular region Molecular Function:protein binding; prolactin receptor binding; hormone activity Biological Process: lactation; cell proliferation; cell surface receptor linked signal transduction; regulation of multicellular organism growth; positive regulation of JAK-STAT cascade; female pregnancy |
| NCBI Summary: | This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P01236 |
| NCBI GenInfo Identifier: | 130930 |
| NCBI Gene ID: | 5617 |
| NCBI Accession: | P01236.1 |
| UniProt Secondary Accession: | P01236,Q15199, Q92996, |
| UniProt Related Accession: | P01236 |
| Molecular Weight: | 25,876 Da |
| NCBI Full Name: | Prolactin |
| NCBI Synonym Full Names: | prolactin |
| NCBI Official Symbol: | PRL |
| NCBI Protein Information: | prolactin; decidual prolactin |
| UniProt Protein Name: | Prolactin |
| UniProt Gene Name: | PRL |
| UniProt Entry Name: | PRL_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PRL antibody (CAB1618) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
 | Immunofluorescence analysis of HeLa cells using PRL antibody (CAB1618). |
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